E-3-[4-n-Butyl-3-[(7-carboxy-4-methoxy)naphthyl]thien-2-yl]-2-[(2-methoxy-4,5-methylenedioxyphenyl)methyl]-2-propenoic acid | 531491-81-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: E-3-[4-n-Butyl-3-[(7-carboxy-4-methoxy)naphthyl]thien-2-yl]-2-[(2-methoxy-4,5-methylenedioxyphenyl)methyl]-2-propenoic acid
• 英文别名: 8-[4-butyl-2-[(E)-2-carboxy-3-(6-methoxy-1,3-benzodioxol-5-yl)prop-1-enyl]thiophen-3-yl]-5-methoxynaphthalene-2-carboxylic acid
• CAS: 531491-81-3
• 化学式: C₃₂H₃₀O₈S
• 分子量: 574.651
• InChiKey: UPHCFGAMIPRDQU-KGENOOAVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.6
• 重原子数：
  41
• 可旋转键数：
  11
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  140
• 氢给体数：
  2
• 氢受体数：
  9

文献信息

• ENDOTHELIN RECEPTOR ANTAGONISTS
  申请人：SMITHKLINE BEECHAM CORPORATION

  公开号：EP0925297A1

  公开（公告）日：1999-06-30
• EP0925297A4
  申请人：——

  公开号：EP0925297A4

  公开（公告）日：1999-06-30
• Method and Composition for Potentiating the Antipyretic Action of a Nonopiod Analgesic
  申请人：Gulati Anil

  公开号：US20080207763A1

  公开（公告）日：2008-08-28

  A composition and method of treating fever, and optionally treating pain, is disclosed. The composition and method utilize a nonopioid analgesic and an endothelin antagonist as active agents to treat fever in mammals, including humans. The composition also is useful in the prevention and treatment of stroke and other cardiovascular disorders, like myocardial infarction.
• Diagnostic Use of Endothelin Etb Receptor Agonists and Eta Receptor Antagonists in Tumor Imaging
  申请人：Gulati Anil

  公开号：US20080260634A1

  公开（公告）日：2008-10-23

  Methods of imaging tumors are disclosed. The methods utilize an endothelin ET B receptor agonist or an endothelin ET A receptor antagonist, in combination with an imaging agent, to detect a tumor in mammals, including humans.
• Method and Composition for Treating Alzheimer's Disease and Dementias of Vascular Origin
  申请人：Gulati Anil

  公开号：US20100173872A1

  公开（公告）日：2010-07-08

  A composition and method of treating Alzheimer's disease or a dementia of vascular origin are disclosed. The composition and method utilize an endothelin antagonist as the active agent to treat Alzheimer's disease or a dementia of vascular origin in mammals, including humans.