2-[2-[7-[3-(carboxymethyl)-1,1-dimethylbenzo[e]indol-3-ium-2-yl]hepta-2,4,6-trienylidene]-1,1-dimethylbenzo[e]indol-3-yl]acetic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 2-[2-[7-[3-(carboxymethyl)-1,1-dimethylbenzo[e]indol-3-ium-2-yl]hepta-2,4,6-trienylidene]-1,1-dimethylbenzo[e]indol-3-yl]acetic acid
• 化学式: C39H37N2O4+
• 分子量: 597.7
• InChiKey: ULRGZNJZHDYVST-UHFFFAOYSA-O

计算性质

• 辛醇/水分配系数(LogP)：
  8.7
• 重原子数：
  45
• 可旋转键数：
  8
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  80.8
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• [EN] FLUORESCENT SOLID LIPID NANOPARTICLES COMPOSITION AND PREPARATION THEREOF<br/>[FR] COMPOSITION DE NANOPARTICULES LIPIDES SOLIDES FLUORESCENTES ET SA PRÉPARATION
  申请人：BRACCO IMAGING SPA

  公开号：WO2014191467A1

  公开（公告）日：2014-12-04

  The present invention discloses a solid lipid nanoparticle (SLN) comprising: a) a solid lipid core comprising at least a glyceride and/or at least a fatty acid; b) a mixture of amphiphilic components forming a shell around said core a); c) an alkaline-earth complex with a compound of formula I and/or II: d) at least a fluorescent dye selected from: a cyanine fluorescent dye and /or a polyetherocyclic compound selected from: coumarin, pyrano, quinoline, pyranoquinoline, indole and pyranoindole derivates in acid form or a pharmaceutically acceptable salt thereof. These nanoparticles allow a prolonged blood circulation half-life, show enhanced photostability and improved fluorescence signal. The dye is preserved from degradation and improves the fluorescent quantum yield.

  本发明公开了一种固体脂质纳米粒子（SLN），包括：a）至少包括一种甘油酯和/或至少一种脂肪酸的固体脂质核心；b）形成围绕所述核心a）的壳层的两性分子成分混合物；c）与式I和/或II的化合物形成的碱土金属络合物；d）至少选择自：青菁荧光染料和/或选择自：香豆素、吡喍、喹啉、吡喍喹啉、吲哚和吡喍吲哚衍生物的多醚环化合物的荧光染料；以及其在酸形式或其药学上可接受的盐中。这些纳米粒子允许延长血液循环半衰期，显示增强的光稳定性和改善的荧光信号。染料免受降解并提高荧光量子产率。
• NOVEL INDOCYANINE COMPOUND, SYNTHESIS METHOD AND PURIFICATION METHOD THEREOF, DIAGNOSTIC COMPOSITION USING THE INDOCYANINE COMPOUND, AND DEVICE FOR MEASURING BIOKINETICS AND DEVICE FOR VISUALIZING CIRCULATION USING THE DIAGNOSTIC COMPOSITION
  申请人：Teranishi Katsunori

  公开号：US20120302881A1

  公开（公告）日：2012-11-29

  The present invention aims at providing a novel indocyanine compound solving problems of conventionally used indocyanine green, such as solubility in water or physiological saline, a synthesis method and a purification method thereof, and a diagnostic composition including the novel indocyanine compound. Further, provided are a method for evaluating biokinetics of the novel indocyanine compound and a device for measuring biokinetics, and a method and a device for visualizing circulation of fluid such as blood in a living body, which utilize the diagnostic composition. Also, found are a novel indocyanine compound in which a hydrophobic moiety in a near-infrared fluorescent indocyanine molecule is included in a cavity of a cyclic sugar chain cyclodextrin to cover the hydrophobic moiety in the indocyanine molecule with the glucose, and a synthesis method and a purification method thereof. Furthermore, found are a method for fluorescence-imaging an organ other than liver by intravenous administration, a method for evaluating biokinetics of the novel indocyanine compound, a device for measuring biokinetics, and a method and a device for visualizing circulation of fluid such as blood in a living body, utilizing the diagnostic composition including the novel indocyanine compound.