6-[4-(2-(2-(1-Piperidinyl)ethoxy)-ethoxy)-naphthalen-1-yl]-pyridin-2-ylamine

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 6-[4-(2-(2-(1-Piperidinyl)ethoxy)-ethoxy)-naphthalen-1-yl]-pyridin-2-ylamine
• 英文别名: 6-[4-[2-(2-Piperidin-1-ylethoxy)ethoxy]naphthalen-1-yl]pyridin-2-amine
• 化学式: C₂₄H₂₉N₃O₂
• 分子量: 391.513
• InChiKey: MLQXZNAIYKZANY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  29
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  60.6
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• 2-aminopyridines containing fused ring substituents
  申请人：——

  公开号：US20010014689A1

  公开（公告）日：2001-08-16

  The present invention relates to 2-aminopyridine derivatives of the formula I: 1 or pharmaceutically acceptable salts thereof, wherein A and B are each independently H, or together, A and B form a ring fused to the phenyl ring, said ring being saturated or unsaturated and containing from 5 to 7 ring member atoms, where said ring member atoms may optionally comprise from 1 to 2 heteroatoms selected independently from the group consisting of N, O or S, provided that no two adjacent ring members are heteroatoms; X is oxygen or a single bond; Y is (C 1 -C 6 )alkyl; R 1 is hydrogen, (C 1 -C 6 )alkyl or a (C 1 -C 6 alkyl) group substituted with —NR 2 R 3 wherein R 2 and R 3 are either selected independently from the group consisting of H, alkyl, aryl, aralkyl or tetrahydronaphthalene, wherein said aryl group or said aryl moiety of said aralkyl group is phenyl or naphthyl, said alkyl group or said alkyl moiety of said aralkyl group contains from one to six carbon atoms and is straight-chained or branched, and said aryl group, said tetrahydronaphthalene or said aryl moiety of said aralkyl group is optionally substituted with from one to three of halogen, nitro, cyano, amino, (C 1 -C 4 )alkoxy and (C 1 -C 4 )alkylamino moieties, or R 2 and R 3 form, together with the nitrogen to which they are attached, a heterocyclic ring, or a cyclic or bicyclic ring which is saturated or unsaturated. The compounds of the invention have the ability to inhibit the activity of nitric oxide synthases (NOS), and hence, are useful in the treatment of diseases, conditions and disorders of the central nervous system, among others.

  本发明涉及式I的2-氨基吡啶衍生物或药学上可接受的盐，其中A和B各自独立地为H，或者一起，A和B形成一个螺合到苯环上的环，该环饱和或不饱和，含有5至7个环成员原子，其中该环成员原子可以选择性地包括从N，O或S组成的1至2个杂原子，前提是相邻的两个环成员原子不是杂原子；X为氧或单键；Y为（C1-C6）烷基；R1为氢，（C1-C6）烷基或取代为- NR2R3的（C1-C6）烷基，其中R2和R3从H，烷基，芳基，芳基烷基或四氢萘中独立选择，其中所述芳基或所述芳基烷基的芳基基团是苯基或萘基，所述烷基或所述芳基烷基的烷基基团含有1至6个碳原子，并且是直链或支链的，所述芳基基团，所述四氢萘或所述芳基烷基的芳基基团可以选择性地取代1至3个卤素，硝基，氰基，氨基，（C1-C4）烷氧基和（C1-C4）烷基氨基基团，或R2和R3与它们所附着的氮一起形成一个杂环，或者形成一个饱和或不饱和的环或二环。本发明化合物具有抑制一氧化氮合酶（NOS）活性的能力，因此，在中枢神经系统等疾病，病症和障碍的治疗中有用。
• 2-AMINOPYRIDINES CONTAINING FUSED RING SUBSTITUENTS
  申请人：Pfizer Products Inc.

  公开号：EP1155000B1

  公开（公告）日：2003-07-16
• US6211208B1
  申请人：——

  公开号：US6211208B1

  公开（公告）日：2001-04-03
• US6372768B2
  申请人：——

  公开号：US6372768B2

  公开（公告）日：2002-04-16
• [EN] 2-AMINOPYRIDINES CONTAINING FUSED RING SUBSTITUENTS<br/>[FR] 2-AMINOPYRIDINES CONTENANT DES SUBSTITUANTS A CYCLES CONDENSES
  申请人：PFIZER PROD INC

  公开号：WO2000050400A1

  公开（公告）日：2000-08-31

  The present invention relates to 2-aminopyridine derivatives of formula (I) or pharmaceutically acceptable salts thereof, wherein A and B are each independently H, or together, A and B form a ring fused to the phenyl ring, said ring being satured or unsatured and containing from 5 to 7 ring member atoms, where said ring member atoms may optionally comprise from 1 to 2 heteroatoms selected independently from the group consisting of N, O or S, provided that no two adjacent ring members are heteroatoms; X is oxygen or a single bond; Y is (C1-C6)alkyl; R1 is hydrogen, (C¿1?-C6)alkyl or a (C1-C6 alkyl) group substituted with -NR?2R3¿ wherein R?2 and R3¿ are either selected independently from the group consisting of H, alkyl, aryl, aralkyl or tetrahydronaphthalene, wherein said aryl group or said aryl moiety of said aralkyl group is phenyl or naphthyl, said alkyl group or said alkyl moiety of said aralkyl group contains from one to six carbon atoms and is straight-chained or branched, and said aryl group, said tetrahydronaphthalene or said aryl moiety of said aralkyl group is optionally substituted with from one to three of halogen, nitro, cyano, amino, (C¿1?-C4)alkoxy and (C1-C4)alkylamino moieties, or R?2 and R3¿ form, together with the nitrogen to which they are attached, a heterocyclic ring, or a cyclic or bicyclic ring which is saturated or unsaturated. The compounds of the invention have the ability to inhibit the activity of nitric oxide synthases (NOS), and hence, are useful in the treatment of diseases, conditions and disorders of the central nervous system, among others.