N-[(2S)-3-hydroxy-1-[[(2S)-1-[(2R)-2-(hydroxymethyl)oxiran-2-yl]-4-methyl-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]-5-methoxy-1,2,3,4-tetrahydronaphthalene-2-carboxamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: N-[(2S)-3-hydroxy-1-[[(2S)-1-[(2R)-2-(hydroxymethyl)oxiran-2-yl]-4-methyl-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]-5-methoxy-1,2,3,4-tetrahydronaphthalene-2-carboxamide
• 化学式: C₂₄H₃₄N₂O₇
• 分子量: 462.5
• InChiKey: MGFMURMIKLITBC-XFLLKONNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  33
• 可旋转键数：
  11
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  138
• 氢给体数：
  4
• 氢受体数：
  7

文献信息

• EPONEMYCIN AND EPOXOMICIN ANALOGS AND USES THEREOF
  申请人：Agoulnik Sergei

  公开号：US20090291998A1

  公开（公告）日：2009-11-26

  The present invention provides compounds having formula (1): wherein R 1 -R 6 , A, J, D, A, G, Q, w, x, y, and z are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof in the treatment of cancer and/or inflammatory disorders, and more generally as proteasome inhibitors.
• US7524883B2
  申请人：——

  公开号：US7524883B2

  公开（公告）日：2009-04-28