(E)-3-(3,5-dimethoxyphenyl)-2-[4-[4-(3-methoxy-2-methoxycarbonyl-3-oxoprop-1-enyl)phenoxy]phenyl]prop-2-enoic acid

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: (E)-3-(3,5-dimethoxyphenyl)-2-[4-[4-(3-methoxy-2-methoxycarbonyl-3-oxoprop-1-enyl)phenoxy]phenyl]prop-2-enoic acid
• 化学式: C₂₉H₂₆O₉
• 分子量: 518.5
• InChiKey: NACOOZVEKADDCT-PCLIKHOPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  38
• 可旋转键数：
  12
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  118
• 氢给体数：
  1
• 氢受体数：
  9

文献信息

• Compounds for treatment of inflammation, diabetes and related disorders
  申请人：Neogi Partha

  公开号：US20080188654A1

  公开（公告）日：2008-08-07

  Novel acyl urea, thiourea, carbamate, thiocarbamate and related compounds are provided which are effective in inhibiting the cytokine-mediated inflammatory response in cultured cells, in ameliorating bone destruction in an animal model of arthritis and in lowering blood glucose levels in animal models of Type II diabetes mellitus. The compounds are disclosed as useful for a variety of treatments including the treatment of diabetes mellitus, insulin resistance, inflammation, inflammatory, diseases, immunological diseases and cancer.

  提供了一种新型酰基脲、硫脲、氨基甲酸酯、硫代氨基甲酸酯及其相关化合物，这些化合物在培养细胞中有效抑制细胞因子介导的炎症反应，在动物关节炎模型中改善骨破坏，并在二型糖尿病动物模型中降低血糖水平。这些化合物被揭示为用于多种治疗，包括糖尿病、胰岛素抵抗、炎症、免疫性疾病和癌症的治疗。
• COMPOUNDS FOR TREATMENT OF INFLAMMATION, DIABETES AND RELATED DISORDERS
  申请人：Neogi Partha

  公开号：US20070259961A9

  公开（公告）日：2007-11-08

  Novel acyl urea, thiourea, carbamate, thiocarbamate and related compounds are provided which are effective in inhibiting the cytokine-mediated inflammatory response in cultured cells, in ameliorating bone destruction in an animal model of arthritis and in lowering blood glucose levels in animal models of Type II diabetes mellitus. The compounds are disclosed as useful for a variety of treatments including the treatment of diabetes mellitus, insulin resistance, inflammation, inflammatory diseases, immunological diseases and cancer.

  提供了一系列新型酰基脲、硫脲、氨基甲酸酯、硫代氨基甲酸酯及相关化合物，这些化合物在培养细胞中抑制细胞因子介导的炎症反应、改善关节炎动物模型中的骨破坏和降低2型糖尿病动物模型中的血糖水平方面具有有效性。这些化合物被披露为用于多种治疗，包括糖尿病、胰岛素抵抗、炎症、炎症性疾病、免疫疾病和癌症的治疗。
• US7323496B2
  申请人：——

  公开号：US7323496B2

  公开（公告）日：2008-01-29