(Z)-but-2-enedioic acid;6-methyl-2-piperazin-1-yl-7H-pyrrolo[3,4-d]pyrimidin-5-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: (Z)-but-2-enedioic acid;6-methyl-2-piperazin-1-yl-7H-pyrrolo[3,4-d]pyrimidin-5-one
• 化学式: C15H19N5O5
• 分子量: 349.34
• InChiKey: DCEXWCBDEHBHCI-BTJKTKAUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.82
• 重原子数：
  25
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  136
• 氢给体数：
  3
• 氢受体数：
  9

反应信息

• 作为产物：
  描述：

  6-methyl-2-piperazin-1-yl-7H-pyrrolo[3,4-d]pyrimidin-5-one 、 顺丁烯二酸 生成 (Z)-but-2-enedioic acid;6-methyl-2-piperazin-1-yl-7H-pyrrolo[3,4-d]pyrimidin-5-one
  参考文献：
  名称：

  AWAYA, AKIRA;NAKANO, TAKUO;KOBAYASHI, HISASHI;TAN, KEN E.;HORIKOMI, KAZUT+

  摘要：

  DOI：

文献信息

• Wound-healing agent
  申请人：MITSUI PHARMACEUTICALS, INC.

  公开号：EP0743066A2

  公开（公告）日：1996-11-20

  The present invention provides a method for the screening of a wound-healing agent, which comprises determining a substance to be active as a wound-healing agent on the basis of potentiation or modification of biological activities of a growth and/or differentiation factor, a growth hormone or a cytokine. This invention also provides a wound-healing agent, which comprises as an active ingredient a compound of the following formula (1) or formula (2).

  本发明提供了一种筛选伤口愈合剂的方法，该方法包括根据生长和/或分化因子、生长激素或细胞因子的生物活性的增强或改变来确定一种物质作为伤口愈合剂的活性。本发明还提供了一种伤口愈合剂，其活性成分包括下式（1）或式（2）的化合物。
• Combination therapy to improve brain function or promote neurogenesis for treating neurodegenerative conditions
  申请人：UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC.

  公开号：US10751340B2

  公开（公告）日：2020-08-25

  Disclosed herein are methods and materials for improving brain function and/or promoting neurogenesis m a patient suffering from impaired brain function. Specifically exemplified herein ls the co-administration of phenserine and NBI-18. A method of treating a neurodegenerative disease in a patient in need thereof, said method comprising co-administering to the patient phenserine, or pharmaceutically acceptable salt thereof, and NBI-18, or pharmaceutically acceptable salt thereof, in respective amounts and frequency such that they work together to improve brain function or induce neurogenesis in the patient.

  本文公开了用于改善脑功能和/或促进脑功能受损患者神经发生的方法和材料。在此具体举例说明的是联合给药芬丝林和 NBI-18。一种治疗有需要的患者的神经退行性疾病的方法，所述方法包括以各自的用量和频率向患者联合给药表皮生长因子或其药学上可接受的盐和NBI-18或其药学上可接受的盐，使它们共同作用以改善患者的脑功能或诱导神经发生。
• COMPOSITIONS FOR TREATING OR DELAYING THE ONSET OF HAIR LOSS
  申请人：University Of Central Florida Research Foundation, Inc.

  公开号：EP2326330B1

  公开（公告）日：2015-01-07
• COMBINATION THERAPY TO IMPROVE BRAIN FUNCTION OR PROMOTE NEUROGENESIS FOR TREATING NEURODEGENERATIVE CONDITIONS
  申请人：UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC.

  公开号：US20210046079A1

  公开（公告）日：2021-02-18

  Disclosed herein are methods and materials for improving brain function and/or promoting neurogenesis in a patient suffering from impaired brain function. Specifically exemplified herein is the co-administration of phenserine and NBI-18.
• US5976523A
  申请人：——

  公开号：US5976523A

  公开（公告）日：1999-11-02