2-(10-Hydroxy-3-oxobenzo[c]xanthen-7-yl)benzoic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 2-(10-Hydroxy-3-oxobenzo[c]xanthen-7-yl)benzoic acid
• 化学式: C₂₄H₁₄O₅
• 分子量: 382.4
• InChiKey: MYKAXXOKHDDAIQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  29
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  83.8
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• OPTICAL SYSTEMS AND METHODS FOR RATIONMETRIC MEASUREMENT OF BLOOD GLUCOSE CONCENTRATION
  申请人：Medtronic MiniMed, Inc.

  公开号：EP2989975A1

  公开（公告）日：2016-03-02

  An optical device for determining blood glucose concentration includes an excitation light source that emits an excitation light signal; a fiber optic sensor sized to be positioned within a blood vessel, the sensor being optically coupled to the excitation light source and comprising an indicator system comprising a fluorophore operably coupled to a glucose binding moiety, wherein upon absorption of at least a portion of the excitation light signal, the indicator system emits an emission light signal having an intensity related to the blood glucose concentration. The device also includes a light sensitive module operably coupled to at least the fiber optic sensor, wherein the light sensitive module detects the emission light signal and at least a second light signal, wherein the second light signal is derived from the excitation light source or an optional reference light source. The fluorophore is excited by the excitation light signal and emits at least a first emission light signal and a second emission light signal, wherein the first and second emission light signals are related to glucose concentrations, and wherein a ratio of the first and second emission light signals is glucose insensitive and sensitive to pH. The fluorophore is typically a fluorescent organic dye, and the glucose binding moiety a boronic acid functionalized viologen.

  一种用于测定血糖浓度的光学装置包括：发射激发光信号的激发光源；尺寸可定位在血管内的光纤传感器，该传感器与激发光源光学耦合，并包括指示器系统，该指示器系统包括可操作地与葡萄糖结合分子耦合的荧光团，其中在吸收至少一部分激发光信号时，指示器系统发射强度与血糖浓度相关的发射光信号。该装置还包括一个光敏模块，可操作地耦合到至少光纤传感器，其中光敏模块检测发射光信号和至少第二光信号，其中第二光信号来自激发光源或可选的参考光源。荧光团被激发光信号激发，至少发出第一发射光信号和第二发射光信号，其中第一发射光信号和第二发射光信号与葡萄糖浓度有关，第一发射光信号和第二发射光信号的比值对葡萄糖不敏感，对 pH 值敏感。荧光团通常是荧光有机染料，葡萄糖结合分子是硼酸官能化紫胶。
• OPTICAL DETERMINATION OF PH AND GLUCOSE
  申请人：Markle David R.

  公开号：US20080188722A1

  公开（公告）日：2008-08-07

  Embodiments of the present invention are directed to an optical sensor capable of measuring two analytes simultaneously with a single indicator system. In preferred embodiments, the sensor comprises a fluorescent dye having acid and base forms that facilitate ratiometric pH sensing, wherein the dye is further associated with a glucose binding moiety and configured to generate a signal that varies in intensity with the concentration of glucose.
• OPTICAL SYSTEMS AND METHODS FOR RATIOMETRIC MEASUREMENT OF BLOOD GLUCOSE CONCENTRATION
  申请人：MARKLE DAVID R.

  公开号：US20080188725A1

  公开（公告）日：2008-08-07

  Novel optical devices, methods and systems relating to the detection of glucose, and more particularly to real-time glucose monitoring, are disclosed herein. More particularly, various hardware and methodological means are disclosed for ratiometric correction of optical glucose measurements for artifacts of optical systems.
• EQUILIBRIUM NON-CONSUMING FLUORESCENCE SENSOR FOR REAL TIME INTRAVASCULAR GLUCOSE MEASUREMENT
  申请人：Markle David R.

  公开号：US20090018418A1

  公开（公告）日：2009-01-15

  Embodiments of the present invention relates to analyte sensors. In particular, the preferred embodiments of the present invention relate to non-consuming intravascular glucose sensors based on fluorescence chemistry.
• USE OF AN EQUILIBRIUM INTRAVASCULAR SENSOR TO ACHIEVE TIGHT GLYCEMIC CONTROL
  申请人：Markle William H.

  公开号：US20090177143A1

  公开（公告）日：2009-07-09

  A method for achieving tight glycemic control in a patient in need thereof is disclosed. The method comprises deploying an equilibrium glucose sensor within a blood vessel in the patient, coupling the sensor to a monitor that displays the blood glucose concentration, and administering a blood glucose regulator when the blood glucose concentration varies outside of the predetermined concentration range. The blood glucose regulator is administered in an amount sufficient to return the blood glucose concentration to within the predetermined concentration range, thereby achieving tight glycemic control.