5-cyclohexyloxy-3-(1-methyl-3,6-dihydro-2H-pyridin-4-yl)-1-naphthalen-2-ylsulfonylindole

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 5-cyclohexyloxy-3-(1-methyl-3,6-dihydro-2H-pyridin-4-yl)-1-naphthalen-2-ylsulfonylindole
• 化学式: C₃₀H₃₂N₂O₃S
• 分子量: 500.7
• InChiKey: CEKQLOAFHHLVTR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.5
• 重原子数：
  36
• 可旋转键数：
  5
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  59.9
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• PIPERIDINE-INDOLE COMPOUNDS HAVING 5-HT6 AFFINITY
  申请人：NPS Allelix Corp.

  公开号：EP1173432B9

  公开（公告）日：2008-10-15
• US6133287A
  申请人：——

  公开号：US6133287A

  公开（公告）日：2000-10-17
• [EN] PIPERIDINE-INDOLE COMPOUNDS HAVING 5-HT6 AFFINITY<br/>[FR] COMPOSES PIPERIDINE-INDOL AYANT UNE AFFINITE AVEC 5-HT6
  申请人：ALLELIX BIOPHARMA

  公开号：WO2000063203A1

  公开（公告）日：2000-10-26

  Described herein are indole compounds with affinity for the 5-HT6 receptor, which have general formula (I) wherein, R1 is selected from the group consisting of H and C¿1-4?alkyl; R?2¿ is selected from the group consisting of H, C¿1-4?alkyl and benzyl; ----- represents a single or double bond; R?3¿ is selected from the group consisting of COR5 and SO¿2?R?5; R4a¿ is selected from the group consisting of H, OH, halo, C¿1-4?alkyl and C1-4alkoxy; R?4b¿ is selected from the group consisting of H, hydroxy, halo, C¿3-7?cycloalkyloxy, C1-4alkoxy, C1-4alkyl, benzyloxy, phenoxy, trifluoromethyl, trifluoromethoxy and vinyl; R?4c¿ is selected from the group consisting of H, OH, halo, C¿1-4?alkyl and C1-4alkoxy; R?4d¿ is selected from the group consisting of H, OH, halo, C¿1-4?alkyl and C1-4alkoxy; and R?5¿ is selected from the group consisting of phenyl, pyridyl, thienyl, quinolinyl and naphthyl which are optionally substituted with 1-4 substituents selected from C¿1-4?alkoxy, C1-4alkyl, halo, nitro, trifluoromethyl, trifluoromethoxy, 1,2-methylenedioxy, C1-4alkylcarbonyl, C1-4alkoxycarbonyl and C1-4alkylS-. Also described is the use of the compounds as pharmaceuticals to treat indications where inhibition of the 5-HT6 receptor is implicated, such as schizophrenia.