2-(7,8-dihydro-6H-pyrido[3,4-b]pyrrolizin-5-yl)ethanamine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯并吡啶类
• 英文名称: 2-(7,8-dihydro-6H-pyrido[3,4-b]pyrrolizin-5-yl)ethanamine
• 化学式: C₁₂H₁₅N₃
• 分子量: 201.27
• InChiKey: OJPWHBUVOKMINF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  43.8
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Aza- indolyl derivatives for treating obesity
  申请人：——

  公开号：US20010025039A1

  公开（公告）日：2001-09-27

  Novel compounds of formula (I): 1 wherein X 1 , X 2 , X 3 and X 4 , n, R 1 , R 2 and R 3 are defined in the specification, and pharmaceutically acceptable salts and prodrugs of the compounds of formula (I) have therapeutic uses. These compounds are useful for the treatment of disorders of the central nervous system; damage to the central nervous system; cardiovascular disorders; gastrointestinal disorders; diabetes insipidus, and sleep apnea. They are particularly useful for the treatment of obesity.

  式(I)的新化合物：其中X1、X2、X3和X4、n、R1、R2和R3在规范中有定义，化合物的药物可接受的盐和前药具有治疗用途。这些化合物对于治疗中枢神经系统疾病、中枢神经系统损伤、心血管疾病、胃肠道疾病、尿崩症和睡眠呼吸暂停症等疾病有用。它们特别适用于肥胖症的治疗。
• NEW AZA-INDOLYL DERIVATIVES
  申请人：F. HOFFMANN-LA ROCHE AG

  公开号：EP1274711A1

  公开（公告）日：2003-01-15
• US6583134B2
  申请人：——

  公开号：US6583134B2

  公开（公告）日：2003-06-24
• [EN] NEW AZA-INDOLYL DERIVATIVES<br/>[FR] NOUVEAUX DERIVES AZA-INDOLYLE
  申请人：HOFFMANN LA ROCHE

  公开号：WO2001066548A1

  公开（公告）日：2001-09-13

  The present invention refers to chemical compounds of formula (I) in which X?1, X2, X3 and X4, n, R1, R2 and R3¿ and pharmaceutically acceptable salts and prodrugs thereof, and the use thereof in therapy, particularly for the treatment of disorders of the central nervous system; damage to the central nervous system; cardiovascular disorders; gastrointestinal disorders; diabetes insipidus, and sleep apnea, and particularly for the treatment of obesity.