5-hydroxy-2-dehydro-O-demethylangolensin

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: 5-hydroxy-2-dehydro-O-demethylangolensin
• 英文别名: 1-(2,4,5-trihydroxyphenyl)-2-(4-hydroxyphenyl)-1-oxo-2-propene；2-(4-Hydroxyphenyl)-1-(2,4,5-trihydroxyphenyl)prop-2-en-1-one
• 化学式: C₁₅H₁₂O₅
• 分子量: 272.257
• InChiKey: PJKBFDSWQUHVKJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  98
• 氢给体数：
  4
• 氢受体数：
  5

文献信息

• Isoflavone metabolites
  申请人：Joannou Eustace George

  公开号：US20050222248A1

  公开（公告）日：2005-10-06

  There are disclosed compounds of formulae (I) or (II) in which A is selected from the group consisting of (1), (2), (3) and (4);OH, and one of R 1 and R 2 is selected from H, OH and OCH 3 , and the other of R 1 and R 2 is selected from OH and OCH 3 ; one of R3 and R4 is selected from H, OH and OCH3, and the other of R3 and R4 is selected from OH and OCH3; provided that at least one of the pairs R 1 , R 2 and R 3 , R 4 are both OH; R 5 is selected from OH and OCH 3 ; and ------ denotes a single or double bond; and pharmaceutically acceptable salts and prodrugs thereof. The compounds of the invention are useful for the treatment of hormone-dependent conditions and cancers.

  在公式（I）或（II）中披露了化合物，其中A选自以下组合：（1）、（2）、（3）和（4）；OH，R1和R2中的一个选自H、OH和OCH3，另一个选自OH和OCH3；R3和R4中的一个选自H、OH和OCH3，另一个选自OH和OCH3；前提是R1、R2和R3、R4中至少有一对是OH；R5选自OH和OCH3；以及------表示单键或双键；以及其药学上可接受的盐和前药。该发明的化合物对于治疗激素依赖性疾病和癌症是有用的。
• ISOFLAVONE METABOLITES
  申请人：Joannou George Eustace

  公开号：US20080125481A1

  公开（公告）日：2008-05-29

  There are disclosed compounds of formulae (I) or (II) in which A is selected from the group consisting of (1), (2), (3) and (4); OH, and one of R 1 and R 2 is selected from H, OH and OCH 3 , and the other of R 1 and R 2 is selected from OH and OCH 3 ; one of R3 and R4 is selected from H, OH and OCH3, and the other of R3 and R4 is selected from OH and OCH3; provided that at least one of the pairs R 1 , R 2 and R 3 , R 4 are both OH; R 5 is selected from OH and OCH 3 ; and denotes a single or double bond; and pharmaceutically acceptable salts and prodrugs thereof. The compounds of the invention are useful for the treatment of hormone-dependent conditions and cancers.

  公开了式（I）或（II）的化合物，其中A从（1），（2），（3）和（4）组成的群体中选择；OH，R1和R2中的一个选择自H，OH和OCH3，另一个选择自OH和OCH3；R3和R4中的一个选择自H，OH和OCH3，另一个选择自OH和OCH3；前提是R1，R2和R3，R4中至少有一对是OH；R5选择自OH和OCH3；并表示单键或双键；以及其药学上可接受的盐和前药。本发明的化合物用于治疗激素依赖性疾病和癌症。
• Phenyl-benzyl-ketones
  申请人：Ruane, Michael

  公开号：EP1743881B1

  公开（公告）日：2010-12-22
• TARGETED DRUG DELIVERY
  申请人：NOXOPHARM LIMITED

  公开号：US20190282540A1

  公开（公告）日：2019-09-19

  A method for providing isoflavonoid compounds to the central nervous system comprising the step of rectally administering the compound to an individual in need thereof. This method is useful in the treatment of brain cancers, including glioblastoma multiforme.
• US7056952B1
  申请人：——

  公开号：US7056952B1

  公开（公告）日：2006-06-06