7-(2,2-dioxo-2lambda6-thia-3-azatricyclo[6.3.1.04,12]dodeca-1(11),4,6,8(12),9-pentaen-3-yl)-N-hydroxy-5-methylheptanamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 7-(2,2-dioxo-2lambda6-thia-3-azatricyclo[6.3.1.04,12]dodeca-1(11),4,6,8(12),9-pentaen-3-yl)-N-hydroxy-5-methylheptanamide
• 英文别名: 7-(2,2-dioxo-2λ6-thia-3-azatricyclo[6.3.1.04,12]dodeca-1(11),4,6,8(12),9-pentaen-3-yl)-N-hydroxy-5-methylheptanamide
• 化学式: C₁₈H₂₂N₂O₄S
• 分子量: 362.4
• InChiKey: QQMHSCXWWXMBSD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  25
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  95.1
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Tricyclic lactam and sultam derivatives and their use as histone deacetylase inhibitors
  申请人：——

  公开号：US20040077698A1

  公开（公告）日：2004-04-22

  A compound of formula (I) wherein A and B are optionally substituted cyclohexenyl or phenyl groups, X is carbonyl or sulfonyl, and Y is 5-7 atoms-linker, is useful as histone deacetylase inhibitors, particularly for inhibiting cell proliferation. 1

  式(I)的化合物，其中A和B为可选择的取代环己烯基或苯基，X为羰基或磺酰基，Y为5-7原子链连接体，可用作组蛋白去乙酰化酶抑制剂，特别是用于抑制细胞增殖。
• TRICYCLIC LACTAM AND SULTAM DERIVATIVES AND THEIR USE AS HISTONE DEACETYLASE INHIBITORS
  申请人：F. HOFFMANN-LA ROCHE AG

  公开号：EP1358168B1

  公开（公告）日：2005-08-10
• US7091229B2
  申请人：——

  公开号：US7091229B2

  公开（公告）日：2006-08-15
• [EN] TRICYCLIC LACTAM AND SULTAM DERIVATIVES AND THEIR USE AS HISTONE DEACETYLASE INHIBITORS<br/>[FR] DERIVES DE SULTAMES ET DE LACTAMES TRICYCLIQUES, UTILISATION DE CES DERNIERS EN TANT QU'INHIBITEURS DE L'HISTONE DEACETYLASE
  申请人：HOFFMANN LA ROCHE

  公开号：WO2002062773A1

  公开（公告）日：2002-08-15

  A compound of formula (I) wherein A and B are optionally substituted cyclohexenyl or phenyl groups, X is carbonyl or sulfonyl, and Y is 5-7 atoms-linker, is useful as histone deacetylase inhibitors, particularly for inhibiting cell proliferation.