3,4-dihydro-1H-isoquinolin-2-yl(3,4,6,7-tetrahydroimidazo[4,5-c]pyridin-5-yl)methanone

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 四氢异喹啉
• 英文名称: 3,4-dihydro-1H-isoquinolin-2-yl(3,4,6,7-tetrahydroimidazo[4,5-c]pyridin-5-yl)methanone
• 化学式: C₁₆H₁₈N₄O
• 分子量: 282.34
• InChiKey: WYFPLLBCOPAAKZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  21
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  52.2
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• SUBSTITUTED IMIDAZOLES, THEIR PREPARATION AND USE
  申请人：NOVO NORDISK A/S

  公开号：EP1173438A1

  公开（公告）日：2002-01-23
• US6908926B1
  申请人：——

  公开号：US6908926B1

  公开（公告）日：2005-06-21
• [EN] SUBSTITUTED IMIDAZOLES, THEIR PREPARATION AND USE<br/>[FR] IMIDAZOLES SUBSTITUES, LEUR PREPARATION ET UTILISATION
  申请人：NOVO NORDISK AS

  公开号：WO2000063208A1

  公开（公告）日：2000-10-26

  A novel class of substituted imidazole compounds (I), pharmaceutical compositions comprising them and use thereof in the treatment and/or prevention of diseases and disorders related to the histamine H3 receptor. More particularly, the compounds are useful for the treatment and/or prevention of diseases and disorders, in which an interaction with the histamine H3 receptor is beneficial.