3,6-Diamino-9H-xanthene

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 3,6-Diamino-9H-xanthene
• 英文别名: 9H-xanthene-3,6-diamine
• 化学式: C₁₃H₁₂N₂O
• 分子量: 212.25
• InChiKey: WRCZSYNKKSWEFM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  16
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  61.3
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• FLUORESCENT PROBE FOR DETECTING DIPEPTIDYL PEPTIDASE IV
  申请人：The University of Tokyo

  公开号：US20170157272A1

  公开（公告）日：2017-06-08

  [Problem] To provide a novel fluorescent probe for dipeptidyl peptidase IV, and a detection method and a detection kit using the fluorescent probe. [Solution] A fluorescent probe for detecting dipeptidyl peptidase IV (DPP-IV), said probe comprising a compound represented by formula (I) or a salt, thereof. In formula (I): A and B are either the same or different and independently represent an amino acid residue, provided that A is bonded via an amide bond to NH in an adjacent formula and B is bonded via an amide bond to A; R 1 represents hydrogen atom(s) or 1 to 4 substituents bonded to the benzene ring, said substituents being either the same or different; R 2 , R 3 , R 4 , R 5 , R 6 and R 7 independently represent a hydrogen atom, a hydroxyl group, an alkyl group or a halogen atom; R 8 and R 9 independently represent a hydrogen atom or an alkyl group; and X represents a C 1 -C 5 alkylene group.

  提供一种新颖的荧光探针用于检测二肽基肽酶IV，以及使用该荧光探针的检测方法和检测工具包。一种用于检测二肽基肽酶IV（DPP-IV）的荧光探针，所述探针包括由式（I）表示的化合物或其盐。在式（I）中：A和B可以相同也可以不同，并且独立地代表一个氨基酸残基，前提是A通过酰胺键与相邻式中的NH结合，而B通过酰胺键与A结合；R1代表氢原子或与苯环结合的1至4个取代基，所述取代基可以相同也可以不同；R2、R3、R4、R5、R6和R7独立地代表氢原子、羟基、烷基或卤素原子；R8和R9独立地代表氢原子或烷基；X代表C1-C5烷基基团。
• [EN] NOVEL FLUORINATED RHODAMINES AS PHOTOSTABLE FLUORESCENT DYES FOR LABELLING AND IMAGING TECHNIQUES<br/>[FR] NOUVELLES RHODAMINES FLUORÉES COMME COLORANTS FLUORESCENTS PHOTOSTABLES POUR DES TECHNIQUES DE MARQUAGE ET D'IMAGERIE
  申请人：MAX PLANCK GES ZUR

  公开号：WO2010149190A1

  公开（公告）日：2010-12-29

  The present invention relates to novel fluorinated 3,6- diaminoxanthene compounds derived from the basic structural formula (I) and to their uses as photostable fluorescent dyes, e.g. for immunostainings and spectroscopic and microscopic applications, in particular in conventional microscopy, stimulated emission depletion (STED) reversible saturable optically linear fluorescent transitions (RESOLFT) microscopy, and fluorescence correlation spectroscopy. The claimed compounds are also useful as molecular probes in various spectroscopic applications.

  本发明涉及从基本结构式（I）衍生的新型氟化3,6-二氨基蒽醌化合物及其作为光稳定荧光染料的用途，例如用于免疫染色和光谱学和显微学应用，特别是在常规显微镜、受激发射消融（STED）可逆饱和光学线性荧光转换（RESOLFT）显微镜和荧光相关光谱学中。所述化合物还可用作各种光谱学应用中的分子探针。
• NOVEL FLUORINATED RHODAMINES AS PHOTOSTABLE FLUORESCENT DYES FOR LABELLING AND IMAGING TECHNIQUES
  申请人：Hell Stefan W.

  公开号：US20120135459A1

  公开（公告）日：2012-05-31

  The present invention relates to novel fluorinated 3,6 -diaminoxanthene compounds derived from the basic structural formula (I) and to their uses as photostable fluorescent dyes, e.g. for immunostainings and spectroscopic and microscopic applications, in particular in conventional microscopy, stimulated emission depletion (STED) reversible saturable optically linear fluorescent transitions (RESOLFT) microscopy, and fluorescence correlation spectroscopy. The claimed compounds are also useful as molecular probes in various spectroscopic applications.

  本发明涉及从基本结构式（I）衍生的新型氟化3,6-二氨基蒽醌化合物及其作为光稳定荧光染料的用途，例如用于免疫染色和光谱学和显微学应用，特别是在传统显微镜、受激发射抑制（STED）可逆饱和光学线性荧光转移（RESOLFT）显微镜和荧光相关光谱学中。所述化合物还可用作各种光谱学应用中的分子探针。
• Poly(oxyalkylene) substituted xanthene colorant and method for making the same
  申请人：MILLIKEN RESEARCH CORPORATION

  公开号：EP0527649A2

  公开（公告）日：1993-02-17

  A diamino-xanthene colorant is provided having the following structure : where Y is a poly(oxyalkylene) substituent having a straight or branched polymer chain of at least 3 monomer units selected from ethylene oxide, propylene oxide, butylene oxide and glycidol ; R1 and R2 are independently selected from H, C1-C4 alkyl, C1-C4 alkoxy, Cl, Br and I; X is selected from H, S03-, CO2- and COOR3, where R3 is C1-C4 alkyl or aryl ; and each Z is independently selected from SO3-, CO2-, COOR4, Cl and OH, where R4 is C1-C4 alkyl or aryl, and n is 0, 1, or 2; the colorant is synthesized by condensing two moles of an N,N-bis (poly(oxyalkylene))-p-methoxyaniline and o-formylbenzene sulfonic acid.

  一种二氨基呫吨着色剂具有如下结构 ： 其中 Y 是聚氧亚烷基取代基，具有至少 3 个选自环氧乙烷、环氧丙烷、环氧丁 烷和缩水甘油的单体单元的直链或支链聚合物链； R1 和 R2 独立选自 H、C1-C4 烷基、C1-C4 烷氧基、Cl、Br 和 I； X 选自 H、S03-、CO2- 和 COOR3，其中 R3 为 C1-C4 烷基或芳基；和 每个 Z 独立地选自 SO3-、 -、COOR4、Cl 和 OH，其中 R4 是 C1-C4 烷基或芳基，n 是 0、1 或 2；着色剂是通过缩合两摩尔的 N,N-双（聚氧烷基）-对甲氧基苯胺和邻甲酰基苯磺酸合成的。
• DIAGNOSTIC FOR CANCER
  申请人：The University of Tokyo

  公开号：EP2524702A1

  公开（公告）日：2012-11-21

  An agent for diagnosing cancer comprising, as an active ingredient, a compound represented by the following formula (I) (R1 represents hydrogen atom, or a substituent; R2 to R7 represent hydrogen atom, hydroxyl group, an alkyl group, or a halogen atom; R8 and R9 represent hydrogen atom, or an alkyl group; and X represents a C1-C3 alkylene group), which specifically emits fluorescence in a cancerous tissue within a short time when applied to a part in which presence of a cancerous tissue is suspected.

  一种用于诊断癌症的制剂，其活性成分包括下式（I）所代表的化合物（R1 代表氢原子或取代基；R2 至 R7 代表氢原子、羟基、烷基或卤素原子；R8 和 R9 代表氢原子或烷基；X 代表 C1-C3 亚烷基），该制剂用于怀疑存在癌组织的部位时，可在短时间内在癌组织中特异性地发出荧光。