1-(5-hydroxy-1H-indazol-3-yl)-3-propan-2-ylurea

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡唑类
• 英文名称: 1-(5-hydroxy-1H-indazol-3-yl)-3-propan-2-ylurea
• 化学式: C₁₁H₁₄N₄O₂
• 分子量: 234.25
• InChiKey: LFLLJQDIIBFOGP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  90
• 氢给体数：
  4
• 氢受体数：
  3

文献信息

• Aminoindazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions containing them
  申请人：——

  公开号：US20040254177A1

  公开（公告）日：2004-12-16

  Compounds which are 3-aminoindazole derivatives or pharmaceutically acceptable salts thereof, together with pharmaceutical compositions comprising them are disclosed; these compounds or compositions are useful in the treatment of diseases caused by and/or associated with an altered protein kinase activity such as cancer, cell proliferative disorders, Alzheimer's disease, viral infections, auto-immune diseases and neurodegenerative disorders.

  本发明揭示了3-氨基吲唑衍生物或其药学上可接受的盐，以及包含它们的制药组合物。这些化合物或组合物在治疗由蛋白激酶活性改变引起和/或相关的疾病方面具有用途，例如癌症、细胞增殖性疾病、阿尔茨海默病、病毒感染、自身免疫性疾病和神经退行性疾病。
• AMINOINDAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
  申请人：Pharmacia Italia S.p.A.

  公开号：EP1432416A1

  公开（公告）日：2004-06-30
• US7511136B2
  申请人：——

  公开号：US7511136B2

  公开（公告）日：2009-03-31
• [EN] AMINOINDAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM<br/>[FR] DERIVES D'AMINOINDAZOLE AGISSANT COMME INHIBITEURS DE LA KINASE, PROCEDE DE PRODUCTION ET COMPOSITIONS PHARMACEUTIQUES LES CONTENANT
  申请人：PHARMACIA ITALIA SPA

  公开号：WO2003028720A1

  公开（公告）日：2003-04-10

  Compounds which are 3-aminoindazole derivatives or pharmaceutically acceptable salts thereof, together with pharmaceutical compositions comprising them are disclosed; these compounds or compositions are useful in the treatment of diseases caused by and/or associated with an altered protein kinase activity such as cancer, cell proliferative disorders, Alzheimer's disease, viral infections, auto-immune diseases and neurodegenerative disorders.