1-[[2-(2,3-dihydro-1-benzofuran-5-yl)-1H-imidazol-5-yl]methyl]-4-phenylpiperazine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 1-[[2-(2,3-dihydro-1-benzofuran-5-yl)-1H-imidazol-5-yl]methyl]-4-phenylpiperazine
• 化学式: C₂₂H₂₄N₄O
• 分子量: 360.5
• InChiKey: MLSIGMJYEHPEJK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  27
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  44.4
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• US6288230B1
  申请人：——

  公开号：US6288230B1

  公开（公告）日：2001-09-11
• [EN] 2-(2,3-DIHYDROBENZOFURAN-5-YL)-4-AMINOMETHYLIMIDAZOLES: DOPAMINE RECEPTOR SUBTYPE SPECIFIC LIGANDS<br/>[FR] 2-(2,3-DIHYDROBENZOFURAN-5-YL)-4-AMINOMETHYLIMIDAZOLES; LIGANDS SPECIFIQUES DU SOUS-TYPE DU RECEPTEUR DE DOPAMINE
  申请人：NEUROGEN CORP

  公开号：WO2000018763A2

  公开（公告）日：2000-04-06

  Disclosed are compounds of formula (I): or the pharmaceutically acceptable acid addition salts thereof wherein: n is an integer; R1 represents an organic or inorganic group; R2 represents halogen or C1-C6 alkyl; RN is an alkylene carrying a substituted piperazine, piperidine, or tetrahydropyridine; and R4 is hydrogen or C1-C6 alkyl, which compounds are useful for the treatment and/or prevention of neuropsychological disorders including, but not limited to, schizophrenia, mania, dementia, depression, anxiety, compulsive behavior, substance abuse, Parkinson-like motor disorders and motion disorders related to the use of neuroleptic agent (blockade/modulation of dopamine receptors).