ethyl 7-(4,5-dihydro-1H-imidazol-2-yl)-6-(2-methoxyethoxy)-3,4-dihydro-1H-isoquinoline-2-carboxylate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 四氢异喹啉
• 英文名称: ethyl 7-(4,5-dihydro-1H-imidazol-2-yl)-6-(2-methoxyethoxy)-3,4-dihydro-1H-isoquinoline-2-carboxylate
• 化学式: C₁₈H₂₅N₃O₄
• 分子量: 347.4
• InChiKey: HQWFBLSAKLLBPU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  25
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  72.4
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• SYNTHESIS OF SUBSTITUTED AMIDINES
  申请人：ELI LILLY AND COMPANY

  公开号：EP1204644A1

  公开（公告）日：2002-05-15
• [EN] SYNTHESIS OF SUBSTITUTED AMIDINES<br/>[FR] SYNTHESE D'AMIDINES SUBSTITUEES
  申请人：LILLY CO ELI

  公开号：WO2000078725A1

  公开（公告）日：2000-12-28

  The present invention provides a process for preparing amidines starting from carboxylic acid derivatives, in which the carboxylic acid containing moiety is attached to a sp3-, or sp?2- or sp1¿-hybridized carbon atom. The sp2-hybridized carbon atom, to which the carboxylic acid containing moiety is attached to may be part of an aromatic or heteroaromatic or olefinic system.
• [EN] PHARMACEUTICAL COMPOUNDS<br/>[FR] COMPOSES PHARMACEUTIQUES
  申请人：LILLY CO ELI

  公开号：WO2000078724A2

  公开（公告）日：2000-12-28

  This invention relates to certain novel imidazoline compounds and analogues thereof, to their use for the treatment of diabetes, diabetic complications, metabolic disorders, or related diseases where impaired glucose disposal is present, to pharmaceutical compositions comprising them, and to processes for their preparation.