N-[[(6aS,10aS)-1-hydroxy-6,6-dimethyl-3-(2-methyloctan-2-yl)-6a,7,10,10a-tetrahydrobenzo[c]chromen-9-yl]methyl]acetamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: N-[[(6aS,10aS)-1-hydroxy-6,6-dimethyl-3-(2-methyloctan-2-yl)-6a,7,10,10a-tetrahydrobenzo[c]chromen-9-yl]methyl]acetamide
• 化学式: C₂₇H₄₁NO₃
• 分子量: 427.6
• InChiKey: MPLIDKSNUNIYHC-VXKWHMMOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.4
• 重原子数：
  31
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  58.6
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• Novel non-psychotropic cannabinoids
  申请人：Pharmos Corporation

  公开号：EP1785417A2

  公开（公告）日：2007-05-16

  Novel-non-psychotropic cannabinoids are disclosed and pharmaceutical compositions comprising these novel compounds are described for preventing neurotoxicity, neuroinflammation, immune or inflammatory disorders comprising as active ingredient the stereospecific (+) enantiomer, having (3S, 4S) configuration of Δ6 tetrahydrocannabinol type compounds. The compositions are particularly effective in alleviating and even preventing neurotoxicity due to acute injuries to the central nervous system, including mechanical trauma, compromised or reduced blood supply as may occur in cardiac arrest or stroke, or poisonings. They are also effective in the treatment of certain inflammatory disorders and chronic degenerative diseases characterized by neuronal loss and chronic pain including neuropathic pain.

  本发明公开了新型非精神类大麻素，并描述了包含这些新型化合物的药物组合物，用于预防神经毒性、神经炎症、免疫或炎症性疾病，其活性成分包括具有（3S、4S）构型的Δ6 四氢大麻酚型化合物的立体异构（+）对映体。这些成分对减轻甚至预防中枢神经系统急性损伤引起的神经毒性特别有效，这些损伤包括机械性创伤、心脏骤停或中风时可能出现的血液供应受损或减少，或中毒。它们还能有效治疗某些炎症性疾病和以神经元丧失和慢性疼痛（包括神经性疼痛）为特征的慢性退行性疾病。