5-Methyl-1-(4-naphthalen-2-yl-1,3-thiazol-2-yl)pyrazole-4-carboxylic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 5-Methyl-1-(4-naphthalen-2-yl-1,3-thiazol-2-yl)pyrazole-4-carboxylic acid
• 化学式: C₁₈H₁₃N₃O₂S
• 分子量: 335.4
• InChiKey: LFQAFSBEJYDCTQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  96.2
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Bis-aryl thiazole derivatives
  申请人：Amaral Catherine M.

  公开号：US20050215608A1

  公开（公告）日：2005-09-29

  Compounds, compositions and methods are provided that are useful in the treatment or prevention of a condition or disorder mediated by an uncoupling protein. In particular, the compounds of the invention modulate the expression and/or activity of UCP3. The subject compositions are particularly useful in the treatment of obesity and type II diabetes, and associated diseases.

  本发明提供的化合物、组合物和方法可用于治疗或预防由解偶联蛋白介导的病症或紊乱。特别是，本发明的化合物可调节 UCP3 的表达和/或活性。本发明组合物特别适用于治疗肥胖症和 II 型糖尿病及相关疾病。
• US7358267B2
  申请人：——

  公开号：US7358267B2

  公开（公告）日：2008-04-15
• [EN] BIS-ARYL THIAZOLE DERIVATIVES<br/>[FR] DERIVES DE BIS-ARYL THIAZOLE
  申请人：TULARIK INC

  公开号：WO2003002062A2

  公开（公告）日：2003-01-09

  Compounds, compositions and methods are provided that are useful in the treatment or prevention of a condition or disorder mediated by an uncoupling protein. In particular, the compounds of the invention modulate the expression and/or activity of UCP3. The subject compositions are particularly useful in the treatment of obesity and type II diabetes, and associated diseases.