5-N-(1H-indazol-3-yl)-3-N-(1H-indazol-6-yl)-1,2,4-triazine-3,5-diamine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡唑类
• 英文名称: 5-N-(1H-indazol-3-yl)-3-N-(1H-indazol-6-yl)-1,2,4-triazine-3,5-diamine
• 化学式: C₁₇H₁₃N₉
• 分子量: 343.3
• InChiKey: XSGKJNYMEUXSIP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  120
• 氢给体数：
  4
• 氢受体数：
  7

文献信息

• PYRAZOLE COMPOUNDS USEFUL AS PROTEIN KINASE INHIBITORS
  申请人：Bebbington David

  公开号：US20080287444A1

  公开（公告）日：2008-11-20

  This invention describes novel pyrazole compounds of formula III: wherein Z 1 , Z 2 , and Z 3 are as described in the specification; Q is —S—, —O—, —N(R 4 )—, or —CH(R 6 )—; R 1 is T-Ring D, wherein Ring D is a 5-7 membered monocyclic ring or 8-10 membered bicyclic ring selected from aryl, heteroaryl, heterocyclyl or carbocyclyl; and R 2 and R 2′ are as described in the specification. The compounds are useful as protein kinase inhibitors, especially as inhibitors of Aurora-2 and GSK-3, for treating diseases such as cancer, diabetes and Alzheimer's disease.
• US7427681B2
  申请人：——

  公开号：US7427681B2

  公开（公告）日：2008-09-23
• US8304414B2
  申请人：——

  公开号：US8304414B2

  公开（公告）日：2012-11-06