1-(2-Chloro-3,3,4,4,5,5-hexafluoro-cyclopent-1-enyl)-4-methyl-piperazine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 1-(2-Chloro-3,3,4,4,5,5-hexafluoro-cyclopent-1-enyl)-4-methyl-piperazine
• 英文别名: 1-(2-Chloro-3,3,4,4,5,5-hexafluorocyclopenten-1-yl)-4-methylpiperazine
• 化学式: C₁₀H₁₁ClF₆N₂
• 分子量: 308.654
• InChiKey: GFJTWBUOVUCIOK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  19
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  6.5
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  1,2-二氯六氟环戊烯 、 N-甲基哌嗪 在 三乙胺 作用下， 以 苯 为溶剂， 反应 4.0h， 以90%的产率得到1-(2-Chloro-3,3,4,4,5,5-hexafluoro-cyclopent-1-enyl)-4-methyl-piperazine
  参考文献：
  名称：

  Nucleophilic substitution reactions of heterocyclic amines and acyclic diamines with chlorofluoro olefins and hexafluoropropylene oxide

  摘要：

  The reactions of CH3N(H)CH2CH2N(H)CH3, CH3N(H)CH2CH2CH2N(H)CH3, and the cyclic amines piperazine, N-phenylpiperazine, and N-methylpiperazine with both cyclic and acyclic 1,2-dichloroperfluoroolefins are reported. Nucleophilic attack occurs at olefinic carbon, followed, in some cases, by cyclization and beta-elimination A variety of unusual polyfluorinated tertiary amines and heterocycles are synthesized.

  DOI：

  10.1021/jo00080a028

文献信息

• Mir Qui-Chee, Guo Cai-Yun, Kirchmeier Robert L., Shreeve Jeanne M., J. Org. Chem, 59 (1994) N 1, S 173-177
  作者：Mir Qui-Chee, Guo Cai-Yun, Kirchmeier Robert L., Shreeve Jeanne M.

  DOI：——

  日期：——
• Nucleophilic substitution reactions of heterocyclic amines and acyclic diamines with chlorofluoro olefins and hexafluoropropylene oxide
  作者：Qui Chee Mir、Cai Yun Guo、Robert L. Kirchmeier、Jean'ne M. Shreeve

  DOI：10.1021/jo00080a028

  日期：1994.1

  The reactions of CH3N(H)CH2CH2N(H)CH3, CH3N(H)CH2CH2CH2N(H)CH3, and the cyclic amines piperazine, N-phenylpiperazine, and N-methylpiperazine with both cyclic and acyclic 1,2-dichloroperfluoroolefins are reported. Nucleophilic attack occurs at olefinic carbon, followed, in some cases, by cyclization and beta-elimination A variety of unusual polyfluorinated tertiary amines and heterocycles are synthesized.