(8-Phenyl-chroman-3-yl)-dipropyl-amine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: (8-Phenyl-chroman-3-yl)-dipropyl-amine
• 英文别名: 8-phenyl-N,N-dipropyl-3,4-dihydro-2H-chromen-3-amine
• 化学式: C₂₁H₂₇NO
• 分子量: 309.451
• InChiKey: OYEKUFKQGCYWCG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  23
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  12.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  碘苯 、 alkaline earth salt of/the/ methylsulfuric acid 在 copper(l) iodide 、 tris(dibenzylideneacetone)dipalladium (0) 、 三苯胂 作用下， 生成 (8-Phenyl-chroman-3-yl)-dipropyl-amine
  参考文献：
  名称：

  Novel derivatives of 3-(dipropylamino)chroman. Interactions with 5-HT1A and D2A receptors

  摘要：

  Novel 8-aryl and 8-aroyl substituted derivatives of 3-(dipropylamino)chroman are described. The compounds have been prepared by a palladium catalyzed reaction of iodoarenes and a stannylated derivative of [eta(6)-3-(dipropylamino)chroman]Cr(CO)(3). Several of the compounds have high affinity for 5-HT1A receptors whereas the affinity for D-2A receptors is lower, the 8-arylated derivatives being slightly more potent than the 8-aroylated analogues. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(99)00232-2

文献信息

• Novel derivatives of 3-(dipropylamino)chroman. Interactions with 5-HT1A and D2A receptors
  作者：Patrizia Caldirola、Ratan Chowdhury、Lena Unelius、Nina Mohell、Uli Hacksell、Anette M. Johansson

  DOI：10.1016/s0960-894x(99)00232-2

  日期：1999.6

  Novel 8-aryl and 8-aroyl substituted derivatives of 3-(dipropylamino)chroman are described. The compounds have been prepared by a palladium catalyzed reaction of iodoarenes and a stannylated derivative of [eta(6)-3-(dipropylamino)chroman]Cr(CO)(3). Several of the compounds have high affinity for 5-HT1A receptors whereas the affinity for D-2A receptors is lower, the 8-arylated derivatives being slightly more potent than the 8-aroylated analogues. (C) 1999 Elsevier Science Ltd. All rights reserved.