6-[1-methyl-4-(2-naphthyl)-1H-imidazol-5-yl]-thieno[2,3-d]pyrimidin-4-amine

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 6-[1-methyl-4-(2-naphthyl)-1H-imidazol-5-yl]-thieno[2,3-d]pyrimidin-4-amine
• 英文别名: 6-(3-Methyl-5-naphthalen-2-ylimidazol-4-yl)thieno[2,3-d]pyrimidin-4-amine
• 化学式: C₂₀H₁₅N₅S
• 分子量: 357.439
• InChiKey: HIHFGQMRPHFWMC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  26
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  97.9
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Condensed pyridines and pyrimidines with tie2 (tek) activity
  申请人：Luke Arthur Richard William

  公开号：US20050256140A1

  公开（公告）日：2005-11-17

  A compound of the Formula (I), wherein A together with the carbon atoms to which it is attached forms a fused 5-membered heteroaryl ring, wherein said heteroaryl ring contains 1 or 2 heteroatoms selected from O, N and S, and wherein the 5-membered ring containing G is linked to the ring formed by A in the meta position to the bridgehead carbon marked # in Formula (I): G is selected from O, S and NR 5 ; Z is selected from N and CR 6 ; Q 1 is selected from optionally substituted aryl and heteroaryl, and the substituents R 1 to R 6 are as defined in the text for use in the production of an anti-angiogenic effect in a warm blooded animal such as man.

  化合物的式子（I），其中A与其连接的碳原子一起形成一个融合的5元杂环芳基环，其中该杂环芳基环含有1或2个从O，N和S中选择的杂原子，并且含有G的5元环与在式子（I）中被标记为#的桥头碳上的A形成的环在间位连接：G从O，S和NR5中选择；Z从N和CR6中选择；Q1从可选取代的芳基和杂环基中选择，取代基R1到R6如文本中所定义，用于在温血动物如人中产生抗血管生成效应的制备。
• CONDENSED PYRIDINES AND PYRIMIDINES WITH TIE2 (TEK) ACTIVITY
  申请人：AstraZeneca AB

  公开号：EP1537112B1

  公开（公告）日：2006-04-19
• US7427616B2
  申请人：——

  公开号：US7427616B2

  公开（公告）日：2008-09-23