3-(Methylamino)-1-naphthalen-1-ylpropan-1-one

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 3-(Methylamino)-1-naphthalen-1-ylpropan-1-one
• 化学式: C₁₄H₁₅NO
• 分子量: 213.27
• InChiKey: ZTWGJJSIEZWIFN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Process for the preparation of N-monosubstituted beta-amino alcohols
  申请人：Michel Dominique

  公开号：US20100240911A1

  公开（公告）日：2010-09-23

  A process for the preparation of a compound of formula: and/or an addition salt of a proton acid, which process comprises the following steps: (a) reacting a mixture comprising (i) a methyl ketone of formula IV and (ii) a compound of formula: H 2 N—R 2 V and/or an addition salt of proton acid, and (iii) formaldehyde or a source of formaldehyde, in the presence of a solvent, and optionally a proton acid, to afford a β-amino ketone of formula II, and/or an addition salt of a proton acid, and (b) reducing the carbonyl group of said β-amino acid, the first step is carried out at a pressure above 1.5 bar.

  一种制备公式化合物和/或质子酸加成盐的方法，其包括以下步骤：(a)在溶剂和可选的质子酸存在下，反应包含(i)公式IV的甲基酮和(ii)公式H2N-R2V的化合物和/或质子酸加成盐，以及(iii)甲醛或甲醛源的混合物，以得到公式II的β-氨基酮和/或质子酸加成盐，(b)还原所述β-氨基酸的羰基基团，其中第一步在1.5 bar以上的压力下进行。
• Process for the Preparation of N-Monosubstituted beta-Amino Alcohols
  申请人：Lonza AG

  公开号：US20150112086A1

  公开（公告）日：2015-04-23

  A process is disclosed for the preparation of a compound of formula and/or an addition salt of a proton acid, wherein R 1 and R 2 independently represent alkyl, cycloalkyl, aryl or aralkyl, each aryl or aralkyl being optionally further substituted with alkyl, alkoxy and/or halogen.

  公开了一种制备公式化合物和/或质子酸加成盐的过程，其中R1和R2独立地表示烷基，环烷基，芳基或芳基烷基，每个芳基或芳基烷基可以选择进一步用烷基，烷氧基和/或卤素取代。
• PROCESS FOR THE PREPARATION OF N-MONOSUBSTITUTED beta-AMINO ALCOHOLS
  申请人：Michel Dominique

  公开号：US20110004007A1

  公开（公告）日：2011-01-06

  A process is disclosed for the preparation of a compound of formula and/or an addition salt of a proton acid, wherein R 1 and R 2 independently represent alkyl, cycloalkyl, aryl or aralkyl, each aryl or aralkyl being optionally further substituted with alkyl, alkoxy and/or halogen. The process involves reacting a mixture comprising a methyl ketone of formula and a compound of formula H 2 N—R 2 (V) and/or an addition salt of proton acid, and formaldehyde in the presence of a solvent selected from the group consisting of water, aliphatic alcohols, cycloaliphatic alcohols and mixtures thereof, and optionally a proton acid to afford a β-amino ketone of formula and/or an addition salt of a proton acid, and reducing the carbonyl group of said β-amino ketone to afford a compound of formula I, and/or an addition salt of a proton acid wherein the first step is carried out at a pressure above 1.5 bar.

  本发明公开了一种制备式（I）化合物和/或质子酸加合盐的方法，其中R1和R2分别独立地表示烷基，环烷基，芳基或芳基烷基，每个芳基或芳基烷基可以选择进一步取代烷基，烷氧基和/或卤素。该方法包括在水，脂肪醇，环烷醇和其混合物中选择的溶剂存在下，通过反应式为甲基酮和式为H2N-R2（V）和/或质子酸加合盐的混合物以及甲醛来制备β-氨基酮化合物和/或质子酸加合盐，然后还原所述β-氨基酮的羰基基团以制备式I化合物和/或质子酸加合盐，其中第一步在大于1.5巴的压力下进行。
• PROCESS FOR THE PREPARATION OF N -MONOSUBSTITUTED BETA-AMINO ALCOHOLS
  申请人：Lonza AG

  公开号：EP1539673B1

  公开（公告）日：2007-10-03
• US8558014B2
  申请人：——

  公开号：US8558014B2

  公开（公告）日：2013-10-15