1,4,8,11-四氧杂二螺[4.1.4.2]十三烷,6-甲基- | 81705-04-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 中文名称: 1,4,8,11-四氧杂二螺[4.1.4.2]十三烷,6-甲基-
• 中文别名: N-(4-氨基丁基)-5-氯-2-萘磺酰胺
• 英文名称: N-(4-aminobutyl)-5-chloronaphthalene-2-sulfonamide
• CAS: 81705-04-6
• 化学式: C₁₄H₁₇ClN₂O₂S
• 分子量: 312.8
• InChiKey: JJQKICOADUKSNS-UHFFFAOYSA-N

物化性质

• 沸点：
  501.5±56.0 °C(Predicted)
• 密度：
  1.307±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  20
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  80.6
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• 1,2-disubstituted-6-oxo-3-phenyl-piperidine-3-carboxamides and combinatorial libraries thereof
  申请人：——

  公开号：US20030171588A1

  公开（公告）日：2003-09-11

  The invention relates to combinatorial libraries containing two or more novel piperidine-3-carboxamide derivative compounds, methods of preparing the piperidine-3-carboxamide derivative compounds and piperidine-3-carboxamide derivative compounds bound to a resin

  这项发明涉及包含两种或更多新型哌啶-3-羧酰胺衍生物化合物的组合式文库，制备这些哌啶-3-羧酰胺衍生物化合物的方法以及与树脂结合的哌啶-3-羧酰胺衍生物化合物。
• 2-aminobenzoxazole derivatives and combinatorial libraries thereof
  申请人：——

  公开号：US20020161028A1

  公开（公告）日：2002-10-31

  The present invention relates to novel 2-aminobenzoxazole derivative compounds of the following formula: 1 wherein R 1 to R 4 and Z have the meanings provided herein. The invention further relates to combinatorial libraries containing two or more such compounds, as well as methods of preparing 2-aminobenzoxazole derivative compounds.

  本发明涉及以下式子的新型2-氨基苯并噁唑衍生物化合物：其中R1至R4和Z具有本文所提供的含义。本发明还涉及包含两种或更多这类化合物的组合式库，以及制备2-氨基苯并噁唑衍生物化合物的方法。
• N,N, -Substituted s-Aryl-Isothioureas, N,N,N, -Substituted s-Aryl-Isothioureas and combinatorial libraries thereof
  申请人：——

  公开号：US20040010036A1

  公开（公告）日：2004-01-15

  The present invention relates to novel N,N,-Substituted S-Aryl-Isothioureas, and N,N,N′-Substituted S-Aryl-Isothioureas and combinatorial libraries thereof, as well as methods of preparing N,N,-Substituted S-Aryl-Isothioureas, and N,N,N′-Substituted S-Aryl-Isothiourea derivative compounds.

  本发明涉及新型N，N-取代S-芳基-异硫脲，以及N，N，N′-取代S-芳基-异硫脲及其组合库，以及制备N，N-取代S-芳基-异硫脲和N，N，N′-取代S-芳基-异硫脲衍生化合物的方法。
• Peptide deformylase activated prodrugs
  申请人：——

  公开号：US20030091587A1

  公开（公告）日：2003-05-15

  This invention provides a method for inhibiting the growth of a microorganism that expresses Peptide Deformylase by contacting the microorganism with an effective amount of the compound described herein. This method inhibits the growth of gram-positive and gram-negative microorganism, e.g., S. aureus, S. epidermidis, K. pneumoniae, E. aerogenes, E. cloacae, M. catarrhalis, E. coli, E. faecalis, H. influenzae and P. aeruginosa . This method can be practiced in vitro, ex vivo and in vivo. Further provided is a method for alleviating the symptoms of an infection by a Peptide Deformylase expressing microorganism in a subject by administering or delivering to the subject an effective amount of the compound described above.

  本发明提供了一种通过接触微生物与本文所述化合物的有效量来抑制表达肽变形酶的微生物生长的方法。该方法可以抑制革兰氏阳性和革兰氏阴性微生物的生长，例如金黄色葡萄球菌、表皮葡萄球菌、肺炎克雷伯菌、空气发酵肠杆菌、克洛伊氏肠杆菌、痰液产生的杆菌、大肠杆菌、嗜肠球菌、流感嗜血杆菌和铜绿假单胞菌。该方法可以在体外、体外和体内实施。此外，本发明还提供了一种通过向受试者施用或输送上述化合物的有效量来减轻表达肽变形酶的微生物感染症状的方法。
• Thioquinazolinone derivatives and combinatorial libraries thereof
  申请人：——

  公开号：US20040102629A1

  公开（公告）日：2004-05-27

  The present invention relates to novel thioquinazolinone derivative compounds and combinatorial libraries of the following formula: 1 wherein R 1 to R 4 , x and y have the meanings provided herein.

  本发明涉及一种新的噻喹唑酮衍生物化合物和以下公式的组合化学库：1其中R1到R4，x和y具有此处提供的含义。