1,6-双(乙烯基磺酰基)己烷 | 55818-44-5

• 分子结构分类: 有机化合物 - 有机硫化合物 - 磺酰类
• 中文名称: 1,6-双(乙烯基磺酰基)己烷
• 英文名称: 1,6-hexane-(bis-vinylsulfone)
• 英文别名: 1,6-Di(ethenesulfonyl)hexane；1,6-bis(ethenylsulfonyl)hexane
• CAS: 55818-44-5
• 化学式: C₁₀H₁₈O₄S₂
• 分子量: 266.383
• InChiKey: FXVRYTNFLAPWIW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  16
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  85
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-[[(2S)-2-[[(2R)-1-(4-aminophenyl)-3-[bis(carboxymethyl)amino]propan-2-yl]-(carboxymethyl)amino]propyl]-(carboxymethyl)amino]acetic acid 、 1,6-双(乙烯基磺酰基)己烷 在 氢氧化钾 、 甲酸 作用下， 以 水 、 N,N-二甲基甲酰胺 为溶剂， 反应 24.0h， 生成 2-[[(2S)-2-[[(2R)-1-[bis(carboxymethyl)amino]-3-[4-[2-(6-ethenylsulfonylhexylsulfonyl)ethylamino]phenyl]propan-2-yl]-(carboxymethyl)amino]propyl]-(carboxymethyl)amino]acetic acid
  参考文献：
  名称：

  WO2007/28639

  摘要：

  公开号：

文献信息

• HYDROXYALKYL STARCH DERIVATIVES AS REACTANTS FOR COUPLING TO THIOL GROUPS
  申请人：FRESENIUS KABI DEUTSCHLAND GMBH

  公开号：US20160311934A1

  公开（公告）日：2016-10-27

  The present invention relates to a hydroxyalkyl starch (HAS) derivative of formula (I) wherein F1 is a functional group comprising the group —NR′—, with R′ being H or alkyl; L is a spacer bridging F1 and S; wherein HAS′ is the remainder of the HAS molecule, R b and R c are —[(CR 1 R 2 ) m O] n —H and are the same or different from each other; R a is —[(CR 1 R 2 ) m O] n —H with HAS′ being the remainder of the hydroxyalkyl starch molecule, or R a is HAS″ with HAS′ and HAS″ together being the remainder of the hydroxyalkyl starch molecule; R 1 and R 2 are independently hydrogen or an alkyl group having from 1 to 4 carbon atoms, m is 2 to 4, wherein R 1 and R 2 are the same or different from each other in the m groups CR 1 R 2 ; n is from 0 to 6.

  本发明涉及一种羟基烷基淀粉（HAS）衍生物，其化学式为（I），其中F1是包含基团—NR′—的功能基团，其中R′为H或烷基；L是桥接F1和S的间隔物；其中HAS′是HAS分子的剩余部分，Rband Rcare —[(CR1R2)mO]n—H，且彼此相同或不同；Ra是—[(CR1R2)mO]n—H，其中HAS′是羟基烷基淀粉分子的剩余部分，或者Ra是HAS″，其中HAS′和HAS″一起是羟基烷基淀粉分子的剩余部分；R1和R2独立地是氢或具有1至4个碳原子的烷基基团，m为2至4，其中在m个CR1R2基团中，R1和R2彼此相同或不同；n为0至6。
• NONAQUEOUS ELECTROLYTE SOLUTION FOR LITHIUM SECONDARY BATTERY AND LITHIUM SECONDARY BATTERY USING THE SAME
  申请人：Ube Industries, Ltd.

  公开号：EP2138481A1

  公开（公告）日：2009-12-30

  The present invention provides (1) a sulfone compounds having a propargyl group, (2) a nonaqueous electrolytic solution for lithium secondary batteries, which comprises an electrolyte salt dissolved in a nonaqueous solvent and contains a sulfone compound having a specific structure that has an SO2 group with a propargyl group or a vinyl group bonding thereto, in an amount of from 0.01 to 10 % by weight of the nonaqueous electrolytic solution, and which can prevent gas generation and is excellent in battery characteristics such as cycle property and the like, and (3) a lithium secondary battery comprising a positive electrode, a negative electrode and a nonaqueous electrolytic solution of an electrolyte salt dissolved in a nonaqueous solvent, wherein the nonaqueous electrolytic solution contains a sulfone compound having a specific structure, in an amount of from 0.01 to 10 % by weight of the nonaqueous electrolytic solution.

  本发明提供了(1)一种具有丙炔基的砜化合物；(2)一种用于锂二次电池的非水性电解溶液，它包括溶解在非水性溶剂中的电解质盐，并含有一种具有特定结构的砜化合物，该化合物具有一个带有丙炔基或乙烯基的SO2基团，其用量为0.(3) 锂二次电池，包括正极、负极和溶解在非水溶剂中的电解质盐的非水电解溶液，其中非水电解溶液含有具有特定结构的砜化合物，其用量为非水电解溶液重量的 0.01至10%（按非水电解溶液重量计）。
• Synthesis and biological activity of a bivalent nucleotide inhibitor of ribonucleotide reductase
  作者：Xu Wu、Barry S Cooperman

  DOI：10.1016/s0960-894x(00)00481-9

  日期：2000.10

  A novel nucleotide inhibitor (ADP-S-HBES-S-dGTP) of mouse ribonucleotide reductase was designed to span the active site and the allosteric specificity site of the enzyme. The inhibitor contains ADP and dGTP moieties which are linked by 1,6-hexane-(bis-ethylenesulfone), and has a K-i value of 12 muM. (C) 2000 Elsevier Science Ltd. All rights reserved.
• INJECTABLE DENDRIMER HYDROGEL NANOPARTICLES
  申请人：Kannan Rangaramanujam M.

  公开号：US20130136697A1

  公开（公告）日：2013-05-30

  The invention discloses injectable hydrogels which are in the form of crosslinked nano beads or particle in the size range 5 nm to 10 μm, comprising PAMAM dendrimer with asymmetrical peripheral end groups such that one of the terminal groups is involved in formation of hydrogel and the other in involved in the conjugation of drugs or imaging agents and their methods of preparation. The said gel is formed by reaction of the PAMAM dendrimer with asymmetrical end groups with other polymer wherein the other polymer is selected from the group of linear, branched, hyperbranched or star shaped polymers with functionalized terminal groups. The PAMAM dendrimer with asymmetrical terminal groups consists of a Generation 2 and above PAMAM dendrimer with symmetrical end groups modified using the amino acids or their modified forms. The gel disclosed in the present invention is formed as small crosslinked particles in the size range 25 nm to 10 μm and is suitable for injectable delivery of hydrogel to any of the body orifices, tissues by intramuscular or subcutaneous route and ocular delivery for the purpose of therapeutic treatment and imaging.
• US7589070B2
  申请人：——

  公开号：US7589070B2

  公开（公告）日：2009-09-15