1-(1,2-二苯基乙基)-4-甲基哌嗪 | 86360-39-6

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 中文名称: 1-(1,2-二苯基乙基)-4-甲基哌嗪
• 英文名称: 1-(1,2-diphenylethyl)-4-methylpiperazine
• 英文别名: 1-(4-Methyl-piperazino)-1,2-diphenyl-ethan；1-Methyl-4-(1,2-diphenyl-ethyl)-piperazin
• CAS: 86360-39-6
• 化学式: C₁₉H₂₄N₂
• 分子量: 280.413
• InChiKey: NXTSFMFOSFAEGA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  6.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1-methylpiperazine enamine from deoxybenzoin 在 甲酸 作用下， 反应 2.0h， 以24%的产率得到1-(1,2-二苯基乙基)-4-甲基哌嗪
  参考文献：
  名称：

  Nilsson, Asa; Carlson, Rolf, Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry, 1985, vol. 39, # 3, p. 187 - 190

  摘要：

  DOI：

文献信息

• Straightforward three-component synthesis of diarylmethylpiperazines and 1,2-diarylethylpiperazines
  作者：Stéphane Sengmany、Erwan Le Gall、Cédric Le Jean、Michel Troupel、Jean-Yves Nédélec

  DOI：10.1016/j.tet.2007.02.086

  日期：2007.4

  Several functionalized diarylmethylpiperazines and 1,2-diarylethylpiperazines have been synthesized in moderate to high yield according to a one-step three-component coupling between an aromatic or a benzylic organozinc reagent, a piperazine derivative, and an aromatic aldehyde. The procedure can be extended to the synthesis of benzylpiperazine derivatives or beta-arylethylpiperazines toward the use of paraformaldehyde or aliphatic aldehydes. (C) 2007 Elsevier Ltd. All rights reserved.
• 1,2-diarylethylamines for treatment of neurotoxic injury
  申请人：G.D. Searle & Co.

  公开号：EP0346791B1

  公开（公告）日：1994-04-06
• METHODS, COMPOSITIONS, AND KITS FOR THE TREATMENT OF CANCER
  申请人：Haggerty Timothy J.

  公开号：US20140335050A1

  公开（公告）日：2014-11-13

  The invention features methods, compositions, and kits for the administration of an HSP90 inhibitor, OBAA, flunarizine, aphidicolin, damnacanthal, dantrolene, or an analog thereof, alone, or in combination with, e.g., a TAA, an antigen-binding scaffold (e.g., an antibody, a soluble T cell receptor, or a chimeric receptor) specific for a TAA, a cell (e.g., a white blood cell that targets a cancer cell), and/or an IFN-β receptor agonist or an IFN-γ receptor agonist, for the treatment of cancer.
• Nilsson, Asa; Carlson, Rolf, Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry, 1985, vol. 39, # 3, p. 187 - 190
  作者：Nilsson, Asa、Carlson, Rolf

  DOI：——

  日期：——