1-(2,4-二氟苯基)哌啶 | 1345471-75-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 中文名称: 1-(2,4-二氟苯基)哌啶
• 英文名称: 1-(2,4-difluorophenyl)-piperidine
• 英文别名: 1-(2,4-difluorophenyl)piperidin；(2,4-Difluorophenyl)-piperidin；1-(2,4-Difluorophenyl)piperidine
• CAS: 1345471-75-1
• 化学式: C₁₁H₁₃F₂N
• 分子量: 197.228
• InChiKey: DZAKQIMUXDHLRT-UHFFFAOYSA-N

物化性质

• 沸点：
  264.4±30.0 °C(Predicted)
• 密度：
  1.159±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  3

安全信息

• 海关编码：
  2933399090

SDS

2,4-Difluoro-1-piperidinobenzeneMSDS英文版

反应信息

• 作为产物：
  描述：

  四氢吡喃 、 2,4-二氟苯胺 在 四氯化钛 作用下， 以 5,5-dimethyl-1,3-cyclohexadiene 为溶剂， 反应 24.0h， 以80%的产率得到1-(2,4-二氟苯基)哌啶
  参考文献：
  名称：

  四氯化钛介导的由环醚合成N-芳基取代的氮杂环化合物†

  摘要：

  在温和的反应条件下，以中等到良好的产率进行四氯化钛介导的五元和六元环状醚到相应的N-芳基取代的氮杂环的转化。计算研究提出了一种机制，该机制涉及路易斯酸辅助的开环，七元金属环中间体和由金属中心直接参与促进的闭环过程。

  DOI：

  10.1039/c6ra27325d

文献信息

• GROUP-15 CATIONIC COMPOUNDS FOR OLEFIN POLYMERIZATION CATALYSTS
  申请人：——

  公开号：US20020111265A1

  公开（公告）日：2002-08-15

  This description addresses fluorinated amine compounds meeting the general formula R′ i ArF-ER 2 , where ArF is a fluoroaryl group, E is nitrogen or phosphorous, each R is independently a C 1 -C 20 hydrocarbyl group, or the two Rs may connect to form an unsubstituted or substituted C 2 -C 20 cycloaliphatic group, R′ is a C 1 -C 20 hydrocarbyl or halogenated hydrocarbyl, and i is 0, 1 or 2. These compounds may be protonated with strong Bronsted acids to form protonated amine compounds that are useful for the preparation of organometallic catalyst-cocatalyst compounds comprising noncoordinating or weakly coordinating anions. The resulting organometallic catalyst-cocatalyst complexes can be effectively used as olefin polymerization catalysts. High number-average molecular weight polymers at high rates of productivity were observed from the use of metallocene catalyst complexes prepared with [N-pentafluorophenyl pyrrolidinium][tetrakis(pentafluorophenyl)borate] of [N-pentafluorophenyl pyrrolidinium][chloride].

  本说明涉及符合通式 R′ 的氟化胺化合物 i ArF-ER 2 其中 ArF 是氟芳基，E 是氮或磷，每个 R 独立地是 C 1 -C 20 烃基，或两个 R 可连接形成未取代或取代的 C 2 -C 20 环脂族基团，R′是一个 C 1 -C 20 烃基或卤代烃基，i 为 0、1 或 2。这些化合物可以用强勃朗斯特酸质子化，形成质子化胺化合物，用于制备包含非配位或弱配位阴离子的有机金属催化剂-催化剂化合物。由此得到的有机金属催化剂-催化剂复合物可有效地用作烯烃聚合催化剂。使用 [N-pentafluorophenyl pyrrolidinium][tetrakis(pentafluorophenyl)borate] of [N-pentafluorophenyl pyrrolidinium][chloride] 制备的茂金属催化剂络合物，可以观察到生产率高的高平均分子量聚合物。
• Olefin polymerization catalysts derived from Group-15 cationic compounds and processes using them
  申请人：——

  公开号：US20020115806A1

  公开（公告）日：2002-08-22

  Fluorinated amine compounds, R′ i ArF-ER 2 , where ArF is a fluoroaryl substituent, E is nitrogen or phosphorous, each R is independently a C 1 -C 20 hydrocarbyl substituent, or the two R's may be connected to form an unsubstituted or substituted C 2 -C 20 cycloaliphatic substituent, R′ is a C 1 -C 20 hydrocarbyl or halogenated hydrocarbyl, and i is 0, 1 or 2 are disclosed. These compounds may be protonated and complexed with suitable substantially noncoordinating anions to prepare polymerization catalyst components. When these catalyst components are combined with organometallic catalyst precursors, the catalyst precursor is activated to a catalyst. This catalyst is combined with monomer under olefin polymerization conditions to prepare polymer. High number-average molecular weight polymers at high productivity rates were observed from using metallocene catalysts activated with [N-pentafluorophenyl pyrrolidinium][tetrakis(pentafluorophenyl)borate].

  氟化胺化合物，R′ i i ArF-ER 2 其中 ArF 是氟芳基取代基，E 是氮或磷，每个 R 独立地是 C 1 -C 20 烃基取代基，或者两个 R 可以连接形成未取代或取代的 C 2 -C 20 环脂族取代基，R′是 C 1 -C 20 烃基或卤代烃基，i 为 0、1 或 2。这些化合物可以质子化并与合适的基本上不配位的阴离子络合，制备聚合催化剂组分。当这些催化剂组分与有机金属催化剂前体结合时，催化剂前体被活化成催化剂。催化剂在烯烃聚合条件下与单体结合，制备聚合物。使用经 N-五氟苯基吡咯烷硼酸酯和四(五氟苯基)硼酸酯活化的茂金属催化剂，可以观察到生产率高、平均分子量高的聚合物。
• OLEFIN POLYMERIZATION COCATALYSTS DERIVED FROM GROUP-15 CATIONIC COMPOUNDS AND PROCESSES USING THEM
  申请人：ExxonMobil Chemical Patents Inc.

  公开号：EP1252166B1

  公开（公告）日：2005-11-09
• 1,2,4-Triazolo [4,3-A] Pyridine Derivatives And Their Use For The Treatment Of Prevention Of Neurological And Psychiatric Disorders
  申请人：JANSSEN PHARMACEUTICALS, INC.

  公开号：US20170333426A1

  公开（公告）日：2017-11-23

  The present invention relates to methods of treating various central nervous system disorders using novel triazolo[4,3-a]pyridine derivatives of Formula (I) wherein all radicals are as defined in the claims. The compounds according to the invention are positive allosteric modulators of the metabotropic glutamate receptor subtype 2 (“mGluR2”), which are useful for the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which the mGluR2 subtype of metabotropic receptors is involved. The invention is also directed to pharmaceutical compositions comprising such compounds, to processes to prepare such compounds and compositions, and to the use of such compounds for the prevention or treatment of neurological and psychiatric disorders and diseases in which mGluR2 is involved.
• US6489480B2
  申请人：——

  公开号：US6489480B2

  公开（公告）日：2002-12-03