1-(2-(N,N-双-(2-羟基丙基)-氨基)-乙基)-4-(2-羟基丙基)-哌嗪 | 3768-41-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 中文名称: 1-(2-(N,N-双-(2-羟基丙基)-氨基)-乙基)-4-(2-羟基丙基)-哌嗪
• 英文名称: 1-(4-{2-[Bis-(2-hydroxy-propyl)-amino]-ethyl}-piperazin-1-yl)-propan-2-ol
• 英文别名: 1-(2-(N,N-Bis(2-hydroxypropyl)amino)ethyl)-4-(2-hydroxypropyl)piperazine；1-[4-[2-[bis(2-hydroxypropyl)amino]ethyl]piperazin-1-yl]propan-2-ol
• CAS: 3768-41-0
• 化学式: C₁₅H₃₃N₃O₃
• 分子量: 303.445
• InChiKey: CVGZYBYVLMNLGK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  21
• 可旋转键数：
  9
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  70.4
• 氢给体数：
  3
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  N-氨乙基哌嗪 、 methyloxirane 以 甲醇 为溶剂， 生成 1-(2-(N,N-双-(2-羟基丙基)-氨基)-乙基)-4-(2-羟基丙基)-哌嗪
  参考文献：
  名称：

  Zagidullin, R. N., Journal of Organic Chemistry USSR (English Translation), 1990, vol. 26, # 1.2, p. 158 - 161

  摘要：

  DOI：

文献信息

• [EN] POLYAMINE-FATTY ACID DERIVED LIPIDOIDS AND USES THEREOF<br/>[FR] LIPIDOÏDES DÉRIVÉS DE POLYAMINE-ACIDE GRAS ET LEURS UTILISATIONS
  申请人：MASSACHUSETTS INST TECHNOLOGY

  公开号：WO2016004202A1

  公开（公告）日：2016-01-07

  The present disclosure provides polyamine-fatty acid derived lipidoids (e.g., compounds of Formula (I) or (II)) and methods of preparing the lipidoids. A described lipidoid includes R-C(=0)-0- moieties (where R is a lipid moiety), which may be hydrolyzed into non-toxic fatty acids. Also provided are compositions including a described lipidoid and an agent (e.g., polynucleotide, small molecule, peptide, or protein). The present disclosure also provides methods, kits, and uses that involve the lipidoids or compositions for delivering an agent to a subject, tissue, or cell and/or for treating and/or preventing a range of diseases, such as genetic diseases, proliferative diseases, hematological diseases, neurological diseases, immunological diseases, gastrointestinal diseases, respiratory diseases, painful conditions, psychiatric disorders, and metabolic disorders.

  本公开提供了聚胺脂肪酸衍生的脂质体（例如，化合物的化学式（I）或（II））以及制备脂质体的方法。所述脂质体包括R-C(=0)-0-基团（其中R是脂质基团），可以水解为无毒脂肪酸。还提供了包括所述脂质体和药剂（例如，多核苷酸、小分子、肽或蛋白质）的组合物。本公开还提供了涉及脂质体或组合物用于将药剂传递给受体、组织或细胞和/或用于治疗和/或预防一系列疾病的方法、试剂盒和用途，例如遗传疾病、增殖性疾病、血液疾病、神经系统疾病、免疫系统疾病、胃肠道疾病、呼吸系统疾病、疼痛症状、精神障碍和代谢性疾病。
• Chemical mechanical planarization for tungsten-containing substrates
  申请人：AIR PRODUCTS AND CHEMICALS, INC.

  公开号：EP2779217A2

  公开（公告）日：2014-09-17

  Chemical mechanical polishing (CMP) compositions for polishing tungsten or tungsten-containing substrates comprise an abrasive, at least one solid catalyst, a chemical additive selected from the groups consisting of piperazine derivatives, salts of cyanate, and combinations thereof; and a liquid carrier. Systems and processes use the aqueous formulations for polishing tungsten or tungsten-containing substrates.

  用于抛光钨或含钨基材的化学机械抛光（CMP）组合物包括磨料、至少一种固体催化剂、一种选自哌嗪衍生物、氰酸盐及其组合的化学添加剂；以及一种液体载体。系统和工艺使用水性制剂抛光钨或含钨基材。
• Digestion of keratin
  申请人：Resinate Materials Group, Inc.

  公开号：US10030099B2

  公开（公告）日：2018-07-24

  The present invention relates to the chemical digestion of keratin, such as avian feathers and wool. The digestion product is made by heating the feathers or wool with a solvent selected from glycols, alkanolamines, polyamines, and combinations thereof. The resulting digested keratin product is a keratin-derived polyol useful for making polymeric materials such as polyurethanes. The digestion products provide a sustainable alternative to petrochemical based intermediates.

  本发明涉及对鸟类羽毛和羊毛等角蛋白的化学消解。消化产物是用选自乙二醇、烷醇胺、多胺及其组合的溶剂加热羽毛或羊毛制成的。消化后的角蛋白产品是一种角蛋白衍生多元醇，可用于制造聚氨酯等聚合材料。这种消化产品是石油化工中间体的可持续替代品。
• Dispersant suitable for lubricant formulations
  申请人：DOW GLOBAL TECHNOLOGIES LLC

  公开号：US10179885B2

  公开（公告）日：2019-01-15

  A dispersant includes the reaction product of an amine and at least one equivalent of glycidyl ether where the amine is selected from a group consisting of aminoethylpiperazine, bis(2-(piperazin-1-yl)ethyl)amine, 4,4′-methylenebiscyclohexylamine, m-xylenediamine, diethylenetriamine, and triethylenetetramine and where the glycidyl ether has the structure (A), where R is selected from aromatic carbon chains, non-aromatic carbon chains and polyalkylene glycol groups. The dispersant is useful in a lubricant with a base oil for increasing soot dispersibility of the lubricant.

  一种分散剂包括胺和至少一种等量的缩水甘油醚的反应产物，其中胺选自由氨基乙基哌嗪、双(2-(哌嗪-1-基)乙基)胺、4,4′-亚甲基二环己基胺、间二亚甲基二胺、二亚乙基三胺和三亚乙基四胺组成的组、其中缩水甘油醚具有结构 (A)，其中 R 选自芳香族碳链、非芳香族碳链和聚亚烷基二醇基团。该分散剂适用于含有基础油的润滑油，可提高润滑油的烟灰分散性。
• AMINO DERIVATIVES TO PREVENT NEPHROTOXICITY AND CANCER
  申请人：Recepticon Aps

  公开号：EP2139461A2

  公开（公告）日：2010-01-06