(E)-N,N-dimethyl-3-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,9,11,13-heptaenylidene)prop-1-en-1-amine

• 分子结构分类: 有机化合物 - 苯类化合物 - 二苯并环庚烯
• 英文名称: (E)-N,N-dimethyl-3-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,9,11,13-heptaenylidene)prop-1-en-1-amine
• 化学式: C₂₀H₁₉N
• 分子量: 273.4
• InChiKey: MWSWGPOWHMKIRE-VIZOYTHASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• Skin friendly adhesive
  申请人：NITTO DENKO CORPORATION

  公开号：EP2853573A1

  公开（公告）日：2015-04-01

  The present invention provides an adhesive composition, medical tape and patch as well as methods for manufacturing the same, wherein said products allow to combine excellent skin friendliness with satisfactory adhesion. The adhesive composition of the present invention is characterized by the presence of a polycondensate having a specified molecular weight, and an oil additive in a specified relative amount.

  本发明提供了一种粘合剂组合物、医用胶带和贴片以及制造方法，其中所述产品可兼具极佳的皮肤亲和性和令人满意的粘合性。本发明粘合剂组合物的特点是含有具有特定分子量的聚缩聚物和特定相对量的油添加剂。
• Hydrophilic skin adhesive
  申请人：NITTO DENKO CORPORATION

  公开号：EP2886578A1

  公开（公告）日：2015-06-24

  Provided is an adhesive composition that exhibits tuneable hydrophilic properties. These properties are accomplished by incorporating, at the stage of polycondensation, a polyalkylene oxide into the polyester forming the polymeric base of the adhesive composition. The adhesive composition may optionally comprise an oil component. It may be used for making medical tapes, patches and the like.

  本文提供了一种粘合剂组合物，该组合物具有可调节的亲水性能。这些特性是通过在缩聚阶段将聚环氧烷加入形成粘合剂组合物聚合物基底的聚酯中实现的。粘合剂组合物还可选择包含油成分。它可用于制作医用胶带、贴片等。
• Curable composition and skin adhesive
  申请人：NITTO DENKO CORPORATION

  公开号：EP2957303A1

  公开（公告）日：2015-12-23

  The present invention pertains to compositions containing a polycondensate and optionally an oil component, wherein the polycondensate is derived from a dicarboxylic acid component, a diol component and an ethylenically unsaturated dicarboxylic acid component. The composition of the invention may be cross-linked to yield an adhesive composition. The composition of the invention and the adhesive composition of the invention may be used on substrates such as tapes and patches in the medical field.

  本发明涉及含有聚缩醛和油组分的组合物，其中聚缩醛来自二羧酸组分、二元醇组分和乙烯不饱和二羧酸组分。本发明的组合物可以通过交联产生粘合剂组合物。本发明的组合物和粘合剂组合物可用于医疗领域的胶带和贴片等基材上。
• COMPOSITION FOR DELIVERING PHYSIOLOGICALLY ACTIVE INGREDIENTS INTO BLOOD VESSEL
  申请人：Lemonex Inc.

  公开号：EP3659585A2

  公开（公告）日：2020-06-03

  The composition including porous silica particles according to the present invention may effectively deliver a bioactive material to target tissues or cells in the blood stream by modifying surfaces of the particles to inhibit aggregation and precipitation in the blood. In addition to the above advantage, the embolic composition including porous silica particles according to the present invention has advantages of having specific physical properties such as biodegradability and sustained release thus to achieve excellent embolization effects and targetability toward target tumor tissues or cells, thereby reducing side effects.

  根据本发明，包括多孔二氧化硅颗粒的组合物可以通过改变颗粒表面来抑制血液中的聚集和沉淀，从而有效地向血流中的靶组织或细胞输送生物活性物质。除上述优点外，根据本发明的包括多孔二氧化硅颗粒的栓塞组合物还具有生物可降解性和持续释放性等特定物理性质的优点，从而实现优异的栓塞效果和对靶肿瘤组织或细胞的靶向性，从而减少副作用。
• Physiologically active substance carrier
  申请人：LEMONEX INC.

  公开号：US11129796B2

  公开（公告）日：2021-09-28

  A bioactive substance carrier includes a bioactive substance and porous silica particles supporting the bioactive substance and having a plurality of pores with a diameter of 5 nm to 100 nm. The porous silica particles have particular physical properties, can deliver all various drugs by a supported amount in a sustained manner, and can be parenterally administered.

  生物活性物质载体包括生物活性物质和支撑生物活性物质的多孔二氧化硅颗粒，多孔二氧化硅颗粒具有多个直径为 5 纳米至 100 纳米的孔。 多孔二氧化硅颗粒具有特殊的物理特性，能以持续的方式按支持量输送各种药物，并可进行肠外给药。