disodium;6-methyl-2-[4-[(2Z)-2-(1-oxo-4-sulfonatonaphthalen-2-ylidene)hydrazinyl]phenyl]-1,3-benzothiazole-7-sulfonate

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: disodium;6-methyl-2-[4-[(2Z)-2-(1-oxo-4-sulfonatonaphthalen-2-ylidene)hydrazinyl]phenyl]-1,3-benzothiazole-7-sulfonate
• 化学式: C24H15N3Na2O7S3
• 分子量: 599.6
• InChiKey: UHWROWGHRMZVES-IWINPQBESA-L

计算性质

• 辛醇/水分配系数(LogP)：
  -2.27
• 重原子数：
  39
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.04
• 拓扑面积：
  214
• 氢给体数：
  1
• 氢受体数：
  11

文献信息

• A METHOD FOR THE IDENTIFICATION OF BETA-SHEET AGGREGATED PROTEIN LIGANDS
  申请人：F.Hoffmann-La Roche AG

  公开号：EP2724161A1

  公开（公告）日：2014-04-30
• ENVIRONMENTALLY RESPONSIVE CHROMIC LUMINESCENT MATERIALS WITH IMPROVED HAND
  申请人：Performance Indicator, LLC

  公开号：EP3174953A1

  公开（公告）日：2017-06-07
• ENVIRONMENTALLY RESPONSIVE CHROMATIC LUMINESCENT COMPOSITIONS WITH IMPROVED HAND
  申请人：Bambu Vault LLC

  公开号：EP3174953B1

  公开（公告）日：2020-09-02
• Methylated Peptides Derived from Tau Protein and Their Antibodies for Diagnosis and Therapy of Alzheimer's Disease
  申请人：Ohio State Innovation Foundation

  公开号：US20140294839A1

  公开（公告）日：2014-10-02

  In sporadic Alzheimer's disease, neurofibrillary lesion formation is preceded by extensive post-translational modification of the microtubule associated protein tau. Immunoassays have been developed recently that detect tau in biological specimens, thus providing a means for pre-mortem diagnosis of Alzheimer's disease, which has remained elusive. These assays have been improved by the analysis of relevant post-translational modifications, such as phosphorylation, however opportunity for improvement remains. The present invention addresses this issue by disclosing synthetic methylated peptides derived from the tau protein of paired helical filaments and non-diseased control brain. Alzheimer's disease specificity is provided by the presence or absence of methyl moieties on lysine residues and differences between mono-, di-, and tri-methylation. The methylated peptide is useful as an antigen and a binding partner for identifying compounds that interact with the peptide and the methylated tau protein, including antibodies that can distinguish non-diseased brain from that affected by Alzheimer's disease. The resulting antibodies are useful diagnostically and therapeutically. The compounds that specifically bind to methylated tau proteins are useful for eliminating abnormally methylated tau.
• METHOD FOR THE IDENTIFICATION OF BETA-SHEET AGGREGATED PROTEIN LIGANDS
  申请人：Hoffmann-La Roche Inc.

  公开号：US20140363898A1

  公开（公告）日：2014-12-11

  The present invention provides an assay for the identification of beta-sheet aggregated protein ligands using Thiazine Red R.