dimethyl 2-[3-[(3S,3'S,4'R,6'S,8'R,8'aR)-8'-(6,7-dimethoxy-3,4-dihydro-1H-isoquinoline-2-carbonyl)-6'-(4-hydroxyphenyl)-1',2-dioxo-3',4'-diphenylspiro[1H-indole-3,7'-4,6,8,8a-tetrahydro-3H-pyrrolo[2,1-c][1,4]oxazine]-5-yl]prop-2-ynyl]propanedioate

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: dimethyl 2-[3-[(3S,3'S,4'R,6'S,8'R,8'aR)-8'-(6,7-dimethoxy-3,4-dihydro-1H-isoquinoline-2-carbonyl)-6'-(4-hydroxyphenyl)-1',2-dioxo-3',4'-diphenylspiro[1H-indole-3,7'-4,6,8,8a-tetrahydro-3H-pyrrolo[2,1-c][1,4]oxazine]-5-yl]prop-2-ynyl]propanedioate
• 化学式: C₅₂H₄₇N₃O₁₁
• 分子量: 889.9
• InChiKey: LRUVQMDSTXJVHA-ZJIFALOXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  66
• 可旋转键数：
  12
• 环数：
  9.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  170
• 氢给体数：
  2
• 氢受体数：
  12

文献信息

• DISC-1 PATHWAY ACTIVATORS IN THE CONTROL OF NEUROGENESIS
  申请人：Tsai Li-Huei

  公开号：US20100015130A1

  公开（公告）日：2010-01-21

  The invention relates to methods of treating neurological disorders in a subject, by activating a DISC1 pathway. Methods of promoting neurogenesis in adult neural progenitor cells, enhancing nerve generation and treating GSK3 disorders as well as related compositions are also provided.
• US8263547B2
  申请人：——

  公开号：US8263547B2

  公开（公告）日：2012-09-11