(2R,3R,6S)-3-ethyl-2,6-diphenylpiperidin-4-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: (2R,3R,6S)-3-ethyl-2,6-diphenylpiperidin-4-one
• 化学式: C₁₉H₂₁NO
• 分子量: 279.382
• InChiKey: MLPXDRONNNYCQN-LNLFQRSKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (2R,3R,6S)-3-ethyl-2,6-diphenylpiperidin-4-one 、 异丙基溴化镁 以 乙醚 为溶剂， 反应 18.0h， 以74%的产率得到(3R,4R)-3-ethyl-4-(propan-2-yl)-2,6-bisphenylpiperidin-4-ol
  参考文献：
  名称：

  Synthesis of 4-hydroxy-3,4-dialkyl-2,6-diaryl-piperidine derivatives as potent antimicrobial agent

  摘要：

  A series of 4-hydroxy-3,4-dialkyl-2,6-diaryl-piperidine (712) have been synthesised by reduction of 3-alkyl-2,6-diarylpiperidin-4-one using the Grignard reagent. Structural assignments and conformational analysis of the compounds were established based on the spectral studies. All the piperdin-4-ol derivatives (712) were assayed for antibacterial, antifungal and anthelmintic activities and they exhibited significant results.

  DOI：

  10.1080/14786419.2012.671317
• 作为产物：
  描述：

  苯甲醛 、 2-戊酮 在 盐酸 、 氨 作用下， 以 乙醇 为溶剂， 生成 (2R,3R,6S)-3-ethyl-2,6-diphenylpiperidin-4-one
  参考文献：
  名称：

  Synthesis of 4-hydroxy-3,4-dialkyl-2,6-diaryl-piperidine derivatives as potent antimicrobial agent

  摘要：

  A series of 4-hydroxy-3,4-dialkyl-2,6-diaryl-piperidine (712) have been synthesised by reduction of 3-alkyl-2,6-diarylpiperidin-4-one using the Grignard reagent. Structural assignments and conformational analysis of the compounds were established based on the spectral studies. All the piperdin-4-ol derivatives (712) were assayed for antibacterial, antifungal and anthelmintic activities and they exhibited significant results.

  DOI：

  10.1080/14786419.2012.671317