1-(氯甲酰基)-4-哌啶基乙酸酯 | 496052-32-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 中文名称: 1-(氯甲酰基)-4-哌啶基乙酸酯
• 英文名称: 1-chlorocarbonylpiperidin-4-yl acetate
• 英文别名: 1-Piperidinecarbonyl chloride, 4-(acetyloxy)-；(1-carbonochloridoylpiperidin-4-yl) acetate
• CAS: 496052-32-5
• 化学式: C₈H₁₂ClNO₃
• 分子量: 205.641
• InChiKey: VFQHAVANUPQLCQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  46.6
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1-苄基-4-羟基哌啶 在 吡啶 作用下， 反应 6.0h， 生成 1-(氯甲酰基)-4-哌啶基乙酸酯
  参考文献：
  名称：

  Selective Cleavage of N-Benzyl-Protected Secondary Amines by Triphosgene

  摘要：

  A series of competition experiments has revealed that selective cleavage of N-benzyl-protected secondary amines can be achieved with triphosgene, thereby providing a useful range of carbamoyl chlorides.

  DOI：

  10.1021/jo0263622

文献信息

• THIADIAZOLE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES
  申请人：GRIFFIOEN Gerard

  公开号：US20090054410A1

  公开（公告）日：2009-02-26

  This invention provides specifically substituted 1,2,4-thiadiazole derivatives for use in the treatment of an α-synucleopathy such as Parkinson's disease, diffuse Lewy body disease, traumatic brain injury, amyotrophic lateral sclerosis, Niemann-Pick disease, Hallervorden-Spatz syndrome, Down syndrome, neuroaxonal dystrophy, multiple system atrophy and Alzheimer's disease. This invention also provides various methods for producing such substituted 1,2,4-thiadiazole derivatives.
• US8541406B2
  申请人：——

  公开号：US8541406B2

  公开（公告）日：2013-09-24
• Selective Cleavage of <i>N</i>-Benzyl-Protected Secondary Amines by Triphosgene
  作者：Martin G. Banwell、Mark J. Coster、Michael J. Harvey、John Moraes

  DOI：10.1021/jo0263622

  日期：2003.1.1

  A series of competition experiments has revealed that selective cleavage of N-benzyl-protected secondary amines can be achieved with triphosgene, thereby providing a useful range of carbamoyl chlorides.