1-氮杂二环[2.2.1]庚烷-3-羰基氯化,(1R-内)-(9CI) | 80866-78-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 中文名称: 1-氮杂二环[2.2.1]庚烷-3-羰基氯化,(1R-内)-(9CI)
• 中文别名: N-(氰甲基)-2-萘磺酰胺钠盐
• 英文名称: Sodium N-(cyanomethyl)naphthalene-2-sulphonamidate
• CAS: 80866-78-0
• 化学式: C12H10N2NaO2S
• 分子量: 269.28
• InChiKey: YWXSTNBYIDDXFK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.26
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  78.3
• 氢给体数：
  1
• 氢受体数：
  4

安全信息

• 危险等级：
  6.1(b)

文献信息

• TRP INHIBITORS AND USES THEREOF
  申请人：Ostertag Eric M.

  公开号：US20120148604A1

  公开（公告）日：2012-06-14

  The present invention, relates to methods including compounds, derivatives, antibodies, interfering RNA, biologies, polypeptides, dominant negative effectors, and their use in the treatment of neuropathic pain by inhibition of transient receptor potential (TRP) channels. In another embodiment, this invention relates to inhibitors, antagonists, and agonists of TRPC4. TRPC4 therapeutic agents and modulators include but are not limited to small molecule inhibitors, compounds, amino acid derivatives, polypeptides, RNA interference agents, natural chemicals, ligand derivatives, and ions. TRPC4 therapeutic agents and modulators are developed for the treatment of neuropathic pain, including but not limited to pain sensations such as nociception, hyperalgesia, allodynia, and loss of sensory function.

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