氨基-苯胺基-[1,3,5]三嗪-2-羧酸 | 101080-83-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 三嗪类
• 中文名称: 氨基-苯胺基-[1,3,5]三嗪-2-羧酸
• 英文名称: 4-amino-6-(phenylamino)-1,3,5-triazine-2-carboxylic acid
• 英文别名: amino-anilino-[1,3,5]triazine-2-carboxylic acid；Amino-anilino-[1,3,5]triazin-2-carbonsaeure；4-Amino-6-anilino-1,3,5-triazine-2-carboxylic acid
• CAS: 101080-83-5
• 化学式: C₁₀H₉N₅O₂
• 分子量: 231.214
• InChiKey: NEVWIRAYVGRINZ-UHFFFAOYSA-N

物化性质

• 沸点：
  567.6±33.0 °C(Predicted)
• 密度：
  1.541±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  114
• 氢给体数：
  3
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  氨基-苯胺基-[1,3,5]三嗪-2-羧酸 在 溴 作用下， 生成 N-(4-溴-苯基)-[1,3,5]三嗪-2,4-二胺
  参考文献：
  名称：

  Whose Education Counts? The Added Impact of Adult-Child Education on Physical Functioning of Older Taiwanese

  摘要：

  Objectives. Research has implicated education as an important predictor of physical functioning in old age. Older adults in Taiwan tend to experience tight familial integration and high rates of adult-child coresidency-much more so than is typical in Western cultures-which might imply additional influences stemming from the education of children. This could arise in a number of ways for instance, through the sharing of health-related information between child and parent, the quality of caregiving efforts, monetary assistance for medical and other services, or other psychosocial avenues. Despite this probable association, such hypotheses have rarely been tested. In this study, a nationally representative survey of older Taiwanese was used to examine these concurrent effects.Methods. Outcome variables include the existence of any functional limitations (dichotomously measured) and the severity of functional disorders (ordinally measured). Dichotomous and ordinal logistic models were used.Results. Results suggest that, after adjusting for age, sex, and other factors, both child and respondent education associate with the existence of limitations, but the child's education is more important than the parent's when predicting severity of limitations.Discussion. This implies that models ignoring social network characteristics in determining health outcomes of older adults may be misspecified, at least in some non-Western societies, and calls for further testing in other societies as well.

  DOI：

  10.1093/geronb/57.1.s23
• 作为产物：
  描述：

  {4-氨基-6-(苯基氨基)-[1,3,5]三嗪-2-基}甲醇 在 sodium hydroxide 、 potassium permanganate 、 丙酮 作用下， 生成 氨基-苯胺基-[1,3,5]三嗪-2-羧酸
  参考文献：
  名称：

  Sokolowskaja et al., Zhurnal Obshchei Khimii, 1957, vol. 27, p. 765,769; engl. Ausg. S. 839. 842

  摘要：

  DOI：

文献信息

• Biguanide-Based Synthesis of 1,3,5-Triazine Derivatives with Anticancer Activity and 1,3,5-Triazine Incorporated Calcium Citrate Nanoparticles
  作者：Monnaya Chalermnon、Sarocha Cherdchom、Amornpun Sereemaspun、Rojrit Rojanathanes、Tanatorn Khotavivattana

  DOI：10.3390/molecules26041028

  日期：——

  comparable to the IC50 of cisplatin reference. Moreover, the potential use of the calcium citrate nanoparticles (CaCit NPs) as a platform for drug delivery system was studied on a selected 1,3,5-triazine derivative 2a. Condition optimisation revealed that the source of citrate ions and reaction time significantly influence the morphology, size and %drug loading of the particles. With the optimised conditions

  合成了双胍衍生的 1,3,5-三嗪的 12 种衍生物，这是一类有前途的抗癌剂，并评估了它们对两种结直肠癌细胞系 HCT116 和 SW620 的抗癌活性。 2c和3c是含有邻羟基苯基取代基的衍生物，对两种细胞系的 IC 50在 20–27 µM 范围内表现出最高活性，与顺铂参考品的 IC 50相当。此外，还对选定的 1,3,5-三嗪衍生物2a研究了柠檬酸钙纳米颗粒（CaCit NPs）作为药物递送系统平台的潜在用途。条件优化表明，柠檬酸根离子的来源和反应时间显着影响颗粒的形态、尺寸和载药量。通过优化条件，成功合成了“CaCit- 2a NPs”，尺寸为148±23 nm，载药量高达16.3%。此外，还发现合成的CaCit- 2a NPs中2a的释放具有pH响应性，并且2a可以在酸性癌症环境下受控释放。这项研究的知识对于进一步开发基于 1,3,5-三嗪的抗癌药物具有重要意义，并为未来在 CaCit
• Ridi; Checchi, Annali di Chimica, 1953, vol. 43, p. 816,822
  作者：Ridi、Checchi

  DOI：——

  日期：——