amino-anilino-[1,3,5]triazine-2-carboxylic acid ethyl ester | 93002-58-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 三嗪类
• 英文名称: amino-anilino-[1,3,5]triazine-2-carboxylic acid ethyl ester
• 英文别名: Amino-anilino-[1,3,5]triazin-2-carbonsaeure-aethylester；Ethyl 4-amino-6-anilino-1,3,5-triazine-2-carboxylate
• CAS: 93002-58-5
• 化学式: C₁₂H₁₃N₅O₂
• 分子量: 259.268
• InChiKey: HUVIMFBFGBLGRY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  103
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  amino-anilino-[1,3,5]triazine-2-carboxylic acid ethyl ester 生成 氨基-苯胺基-[1,3,5]三嗪-2-羧酸
  参考文献：
  名称：

  Ridi; Checchi, Annali di Chimica, 1953, vol. 43, p. 816,822

  摘要：

  DOI：
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 盐酸 作用下， 生成 amino-anilino-[1,3,5]triazine-2-carboxylic acid ethyl ester
  参考文献：
  名称：

  Sokolowskaja et al., Zhurnal Obshchei Khimii, 1957, vol. 27, p. 765,769; engl. Ausg. S. 839. 842

  摘要：

  DOI：

文献信息

• Design, synthesis and in vitro anticancer evaluation of 4,6-diamino-1,3,5-triazine-2-carbohydrazides and -carboxamides
  作者：Hend Kothayer、Abdalla A. Elshanawani、Mansour E. Abu Kull、Osama I. El-Sabbagh、Malathy P.V. Shekhar、Andrea Brancale、Arwyn T. Jones、Andrew D. Westwell

  DOI：10.1016/j.bmcl.2013.09.087

  日期：2013.12

  Series of substituted 4,6-diamino-1,3,5-triazine-2-carbohydrazides and -carboxamides have been synthesised, based on molecular modelling of candidate structures related to the previously reported Rad6B-inhibitory diamino-triazinylmethyl benzoate anticancer agents TZ8 and TZ9. Synthesis of the target compounds was readily accomplished in two steps from aryl biguanides via reaction of phenylhydrazine or benzylamines with key 4-amino-6-(arylamino)-1,3,5-triazine-2-carboxylate intermediates. These new triazine derivatives were tested for in vitro anticancer activity against the Rad6B expressing human breast cancer cell lines MDA-MB-231 and MCF-7. Active compounds, such as the triazinyl-carbohydrazides 3a-e, were found to exhibit low micromolar IC50 values particularly in the Rad6B-overexpressing MDA-MB-231 cell line. (C) 2013 Elsevier Ltd. All rights reserved.
• Whose Education Counts? The Added Impact of Adult-Child Education on Physical Functioning of Older Taiwanese
  作者：Z. Zimmer、A. I. Hermalin、H.-S. Lin

  DOI：10.1093/geronb/57.1.s23

  日期：2002.1.1

  Objectives. Research has implicated education as an important predictor of physical functioning in old age. Older adults in Taiwan tend to experience tight familial integration and high rates of adult-child coresidency-much more so than is typical in Western cultures-which might imply additional influences stemming from the education of children. This could arise in a number of ways for instance, through the sharing of health-related information between child and parent, the quality of caregiving efforts, monetary assistance for medical and other services, or other psychosocial avenues. Despite this probable association, such hypotheses have rarely been tested. In this study, a nationally representative survey of older Taiwanese was used to examine these concurrent effects.Methods. Outcome variables include the existence of any functional limitations (dichotomously measured) and the severity of functional disorders (ordinally measured). Dichotomous and ordinal logistic models were used.Results. Results suggest that, after adjusting for age, sex, and other factors, both child and respondent education associate with the existence of limitations, but the child's education is more important than the parent's when predicting severity of limitations.Discussion. This implies that models ignoring social network characteristics in determining health outcomes of older adults may be misspecified, at least in some non-Western societies, and calls for further testing in other societies as well.
• Checchi et al., Annali di Chimica (Rome, Italy), 1954, vol. 44, p. 522,529
  作者：Checchi et al.

  DOI：——

  日期：——
• Ridi; Checchi, Annali di Chimica, 1953, vol. 43, p. 816,822
  作者：Ridi、Checchi

  DOI：——

  日期：——
• Sokolowskaja et al., Zhurnal Obshchei Khimii, 1957, vol. 27, p. 765,769; engl. Ausg. S. 839. 842
  作者：Sokolowskaja et al.

  DOI：——

  日期：——