2'-脱氧肌苷 5'-单磷酸酯 | 3393-18-8

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷酸
• 中文名称: 2'-脱氧肌苷 5'-单磷酸酯
• 中文别名: 2'-脱氧肌苷5'-单磷酸酯
• 英文名称: dIMP
• 英文别名: 2'-Deoxyinosine 5'-monophosphate；[(2R,3S,5R)-3-hydroxy-5-(6-oxo-1H-purin-9-yl)oxolan-2-yl]methyl dihydrogen phosphate
• CAS: 3393-18-8
• 化学式: C₁₀H₁₃N₄O₇P
• 分子量: 332.21
• InChiKey: PHNGFPPXDJJADG-RRKCRQDMSA-N

物化性质

• 密度：
  2.17±0.1 g/cm3(Predicted)
• 物理描述：
  Solid
• 碰撞截面：
  166.8 Ų [M+Na]+ [CCS Type: DT, Method: single field calibrated with Agilent tune mix (Agilent)]

计算性质

• 辛醇/水分配系数(LogP)：
  -2.8
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  156
• 氢给体数：
  4
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  2'-脱氧肌苷 5'-单磷酸酯 在 Adechlorin from Actinomadura sp. ATCC₃₉₃₆₅ 、 2-氧代-戊二酸离子(2-) 、 铁粉 作用下， 生成 2’-chloro-2’-deoxyinosine monophosphate
  参考文献：
  名称：

  Fe2 +和α-酮戊二酸依赖性卤素酶作用于核苷酸底物。

  摘要：

  尽管卤代核苷被用作常见的抗癌和抗病毒药物，但天然存在的卤代核苷很少见。脱除二氯（ade）是2'-氯核苷天然产物，最初从Actinomadura sp。鉴定。ATCC39365。但是，在ade生物合成途径中安装氯气仍然难以实现。本文报道的是Fe 2+-α-酮戊二酸卤化酶AdeV可以在2'-脱氧腺苷单磷酸的C2'位置安装一个氯原子，得到2'-氯-2'-脱氧腺苷单磷酸。此外，2'，3'-二脱氧腺苷-5'-单磷酸酯和2'-脱氧肌苷-5'-单磷酸酯的转化效率相对于2'-转化率分别降低了20倍和2倍。脱氧腺苷一磷酸。AdeV代表Fe 2 + -α-酮戊二酸依赖性卤化酶的第一个实例，该酶将核苷酸转化为氯化类似物。

  DOI：

  10.1002/anie.201914994
• 作为产物：
  描述：

  2'-脱氧肌苷 在 三氯氧磷 、 水 作用下， 反应 4.5h， 以63%的产率得到2'-脱氧肌苷 5'-单磷酸酯
  参考文献：
  名称：

  Fully Automated Continuous Meso-flow Synthesis of 5′-Nucleotides and Deoxynucleotides

  摘要：

  The first continuous meso-flow synthesis of natural and non-natural 5'-nucleotides and deoxynucleotides is described, representing a significant advance over the corresponding in-flask method. By means of this meso-flow technique, a synthesis with time consumption and high-energy consumption becomes facile to generate products with great efficiency. An abbreviated duration, satisfactory output, and mild reaction conditions are expected to be realized under the present procedure.

  DOI：

  10.1021/op5002066

文献信息

• Antisense oligonucleotides for the inhibition of integrin alphaV-subunit expression
  申请人：Hoechst Marion Roussel Deutschland GmbH

  公开号：EP0950709A1

  公开（公告）日：1999-10-20

  The present invention relates to an oligonucleotide or a derivative thereof which has a sequence that corresponds to a part of a nucleic acid which encodes an integrin αv subunit and which has the ability to induce apoptosis, the preparation and the use thereof.

  本发明涉及一种寡核苷酸或其衍生物，其序列与编码整合素 αv 亚基的核酸的一部分相对应，具有诱导细胞凋亡的能力。
• Method of producing nucleic acid molecules with reduced secondary structure
  申请人：Agilent Technologies, Inc.

  公开号：EP1624059A2

  公开（公告）日：2006-02-08

  The present invention provides a system for generating nucleic acid molecules having a reduced ability to hybridize to form intermolecular and intramolecular base pairs between regions of substantial complementarity as compared with nucleic acid molecules having the same nucleotide sequence containing naturally-occurring nucleotides. Furthermore, nucleic acid molecules of the present invention are characterized by the ability to form intermolecular base pairs with other nucleic acid molecules of choice.

  本发明提供了一种生成核酸分子的系统，与具有相同核苷酸序列、含有天然存在的核苷酸的核酸分子相比，本发明的核酸分子具有较低的杂交能力，能够在具有实质性互补性的区域之间形成分子间和分子内碱基对。此外，本发明核酸分子的特点是能够与所选择的其他核酸分子形成分子间碱基配对。
• Use of compounds involved in biosynthesis of nucleic acids to increase yield of bacterial cultures
  申请人：Chr. Hansen A/S

  公开号：EP2251416A1

  公开（公告）日：2010-11-17

  Microbial starter cultures. More specifically, a method for preparing a microbial starter culture wherein the microorganism is inoculated in a culture medium comprising at least one yield enhancing agent selected from the group consisting of a purine base, a pyrimidine base, a nucleoside and a nucleotide. Such microbial starter cultures are useful in the manufacturing of food, feed and pharmaceutical products.

  微生物起始培养物。更具体地说，是一种制备微生物起始培养物的方法，其中将微生物接种在含有至少一种增产剂的培养基中，增产剂选自嘌呤碱、嘧啶碱、核苷和核苷酸组成的组。这种微生物起始培养物可用于食品、饲料和药品的生产。
• LACTIC ACID BACTERIUM FERMENTATION PROMOTER
  申请人：MEIJI CO., LTD

  公开号：EP4083187A1

  公开（公告）日：2022-11-02

  The present invention relates to a lactic acid bacterial fermentation promoter, containing at least one organic acid selected from malic acid and fumaric acid.

  本发明涉及一种乳酸菌发酵促进剂，其中含有至少一种选自苹果酸和富马酸的有机酸。
• Measuring method and composition using kinase
  申请人：ASAHI KASEI PHARMA CORPORATION

  公开号：US10472665B2

  公开（公告）日：2019-11-12

  The present invention provides a measuring method for at least one of a kinase forward reaction substrate, a phosphorylated product thereof, and a precursor thereof, and includes a step of conducting an enzymatic cycling reaction by bringing at least a kinase, a first nucleotide coenzyme of the kinase, and a second nucleotide coenzyme having a different nucleoside moiety from the first nucleotide coenzyme into contact with a sample; a step of detecting a signal corresponding to a change of at least one of the first nucleotide coenzyme and a conversion product thereof, and the second nucleotide coenzyme and a conversion product thereof; and (3) a step of calculating, on the basis of the detected change of the signal, an amount of the kinase forward reaction substrate and/or the phosphorylated product thereof contained in the sample.

  本发明提供了一种激酶正向反应底物、其磷酸化产物及其前体中至少一种的测量方法，包括以下步骤：(1)通过使至少一种激酶、该激酶的第一核苷酸辅酶和具有与第一核苷酸辅酶不同核苷分子的第二核苷酸辅酶与样品接触，进行酶循环反应；(3) 根据检测到的信号变化，计算样品中含有的激酶正向反应底物和/或磷酸化产物的量。