2,2-二乙氧基乙亚氨酸乙酯 | 71648-28-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 甲亚胺酸及其衍生物
• 中文名称: 2,2-二乙氧基乙亚氨酸乙酯
• 中文别名: 6,6-二甲基庚基乙酸酯
• 英文名称: ethyl 2,2-diethoxyethanimidate
• 英文别名: 2,2-diethoxy-acetimidic acid ethyl ester；2,2-Diaethoxy-acetimidsaeure-aethylester；ethyl 2,2-diethoxyacetimidate
• CAS: 71648-28-7
• 化学式: C₈H₁₇NO₃
• mdl: MFCD18800833
• 分子量: 175.228
• InChiKey: VCJBDFPSHPBLAO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  12
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.875
• 拓扑面积：
  51.5
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2,2-二乙氧基乙亚氨酸乙酯 、 (17s,18s,19s,20s)-3⁴,3⁵,7⁴,7⁵,11⁴,11⁵,15⁴,15⁵-octaamino-17,18,19,20-tetraundecyl-2,4,6,8,10,12,14,16-octaoxa-3,7,11,15(1,2),1,5,9,13(1,2,4,5)-octabenzenapentacyclo[11.3.1.1^1,5.1^5,9.1^9,13]icosaphane 在 三氟乙酸 作用下， 以 乙醇 为溶剂， 反应 18.0h， 以77%的产率得到7,21,35,49-Tetrakis(diethoxymethyl)-57,61,65,69-tetra(undecyl)-2,12,16,26,30,40,44,54-octaoxa-6,8,20,22,34,36,48,50-octazaheptadecacyclo[53.15.1.156,70.03,11.05,9.013,68.015,66.017,25.019,23.027,64.029,62.031,39.033,37.041,60.043,58.045,53.047,51]doheptaconta-1(71),3(11),4,6,9,13,15(66),17(25),18,20,23,27,29(62),31(39),32,35,37,41(60),42,45(53),46,49,51,55,58,63,67,70(72)-octacosaene
  参考文献：
  名称：

  官能化的自折叠深空分子的合成，客体结合和金属配位

  摘要：

  描述了一种将供体功能引入自折叠苯并咪唑基深空洞的上边缘的简单方法。上边缘供体通过自我互补的氢键结合和空间填充相互作用，可控制大小合适的客体物种的非共价结合，并且如果引入双齿配位体，则金属介导的自折叠是可能的。

  DOI：

  10.1021/acs.orglett.5b00383
• 作为产物：
  描述：

  2,2-二乙氧基乙酰胺 在 喹啉 、 盐酸 、 phosphorus pentoxide 作用下， 生成 2,2-二乙氧基乙亚氨酸乙酯
  参考文献：
  名称：

  Clinical Applications of Serum Placental Protein 14 (PP14) Measurement in the IVF-ET Cycle

  摘要：

  AbstractObjective: Placental protein 14 (PP14) is known to be one of the endometrial proteins that reflect endometrial functioning throughout the menstrual cycle. In this study, we examined PP14 as a marker for human endometrial receptivity in order to predict the outcome of in vitro fertilization and the embryo‐transfer (IVF‐ET) cycle.Patients and Methods: The subjects were 72 women who had 96 IVF‐ET cycles and who were examined at Tokyo Medical University Hospital during the period of January 1998 to June 1998 because of mechanical or unexplained infertility for a duration of at least 2 years. Serum samples were collected from all patients during treatment cycles, and serum PPI4 concentrations were measured by a newly established enzyme‐linked immunosorbent assay (ELISA).Results: In the pregnant group, serum PP14 concentrations were markedly increased after ET, and a significant difference between the pregnant group and the nonpregnant group was observed 8 days following ET (p < 0.01). PP14 concentrations were higher in patients with endometria that exhibited homogenous patterns and that were more than 7 mm thicker than in other patients, as determined by ultrasound on the day of oocyte collection (p < 0.005). The pregnancy rates of patients with homogeneous patterns were lower than those of patients showing a trilaminar pattern. No pregnancies were observed when serum PP14 concentrations were greater than 6.85 U/l on the day of oocyte collection.Conclusion: PP14 might be a useful marker for human endometrial receptivity to predict the outcome of IVF‐ET cycles.

  DOI：

  10.1111/j.1447-0756.2000.tb01325.x

文献信息

• Clinical Applications of Serum Placental Protein 14 (PP14) Measurement in the IVF-ET Cycle
  作者：Yoshichika Suzuki、Rikikazu Sugiyama、Noritaka Fukumine、Saburo Usuda、Hiroe Itoh、Keiichi Isaka、Masaomi Takayama、Borge Teisner

  DOI：10.1111/j.1447-0756.2000.tb01325.x

  日期：2000.8

  AbstractObjective: Placental protein 14 (PP14) is known to be one of the endometrial proteins that reflect endometrial functioning throughout the menstrual cycle. In this study, we examined PP14 as a marker for human endometrial receptivity in order to predict the outcome of in vitro fertilization and the embryo‐transfer (IVF‐ET) cycle.Patients and Methods: The subjects were 72 women who had 96 IVF‐ET cycles and who were examined at Tokyo Medical University Hospital during the period of January 1998 to June 1998 because of mechanical or unexplained infertility for a duration of at least 2 years. Serum samples were collected from all patients during treatment cycles, and serum PPI4 concentrations were measured by a newly established enzyme‐linked immunosorbent assay (ELISA).Results: In the pregnant group, serum PP14 concentrations were markedly increased after ET, and a significant difference between the pregnant group and the nonpregnant group was observed 8 days following ET (p < 0.01). PP14 concentrations were higher in patients with endometria that exhibited homogenous patterns and that were more than 7 mm thicker than in other patients, as determined by ultrasound on the day of oocyte collection (p < 0.005). The pregnancy rates of patients with homogeneous patterns were lower than those of patients showing a trilaminar pattern. No pregnancies were observed when serum PP14 concentrations were greater than 6.85 U/l on the day of oocyte collection.Conclusion: PP14 might be a useful marker for human endometrial receptivity to predict the outcome of IVF‐ET cycles.
• Synthesis, Guest Binding, and Metal Coordination of Functionalized Self-Folding Deep Cavitands
  作者：Magi Mettry、Melissa P. Moehlig、Richard J. Hooley

  DOI：10.1021/acs.orglett.5b00383

  日期：2015.3.20

  A simple method to introduce donor functions to the upper rim of self-folding benzimidazole-based deep cavitands is described. The upper rim donors allow controlled noncovalent binding of suitably sized guest species via both self-complementary hydrogen bonding and space-filling interactions, and metal-mediated self-folding is possible if bidentate coordinators are incorporated.

  描述了一种将供体功能引入自折叠苯并咪唑基深空洞的上边缘的简单方法。上边缘供体通过自我互补的氢键结合和空间填充相互作用，可控制大小合适的客体物种的非共价结合，并且如果引入双齿配位体，则金属介导的自折叠是可能的。