2,3-二溴-1-丙醇磷酸酯 | 126-72-7

• 物质功能分类: 分析化学 - 标准品 - 挥发性有机化合物(VOCs)
• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磷酸及其衍生物
• 中文名称: 2,3-二溴-1-丙醇磷酸酯
• 中文别名: 2,3-二溴-1-丙醇磷酸酯(3:1)；磷酸三（2、3-二溴丙基）酯；三(2,3-二溴丙醇)磷酸酯；磷酸三(2,3-二溴丙基)酯；磷酸三（2、3-二溴丙基）酯TDBPP
• 英文名称: tris-(2,3-dibromopropyl)phosphate
• 英文别名: TDBPP；TBPP；Tris-(2,3-dibrompropyl)-phosphat；Apex 462-5；Tris(2,3-dibromopropyl) phosphate
• CAS: 126-72-7
• 化学式: C₉H₁₅Br₆O₄P
• mdl: MFCD00039191
• 分子量: 697.613
• InChiKey: PQYJRMFWJJONBO-UHFFFAOYSA-N

物化性质

• 熔点：
  5.5°C
• 沸点：
  544.2±50.0 °C(Predicted)
• 密度：
  2.27 g/cm3(Temp: 25 °C)
• 溶解度：
  可溶于氯仿、甲醇（少许）
• 物理描述：
  Tris(2,3-dibromopropyl) phosphate is a clear colorless to pale yellow viscous liquid. (NTP, 1992)
• 颜色/状态：
  Viscous, pale yellow liquid
• 闪点：
  >112 °C
• 蒸汽压力：
  2.25X10-4 mm Hg at 25 °C
• 稳定性/保质期：

  基本性质：本品的物理化学性质较为稳定，溶于乙醇、丙酮、苯和四氯化碳，而不溶于水。低毒，但对上呼吸道、皮肤和眼角膜有较强的刺激性。操作时应确保装置密闭并保持良好通风，同时佩戴防护眼镜和手套等个人防护用品。

• 分解：
  200 °C. This produces toxic and corrosive fumes including hydrogen bromide and phosphorus oxides. Reacts with acids and bases.
• 粘度：
  High purity grade: 3900-4200 centistokes at 25 °C; low purity grade: 1400-1700 centistokes at 25 °C
• 折光率：
  Index of refraction: 1.5772 @ 20 °C/D
• 保留指数：
  2918.9

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  20
• 可旋转键数：
  12
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  44.8
• 氢给体数：
  0
• 氢受体数：
  4

ADMET

代谢

当100毫克/动物的剂量应用于雄性刘易斯大鼠剃光的皮肤上时，代谢水解产物2,3-二溴丙醇以自由态和结合态在尿液中可检测到数天。

When a dose of 100 mg/animal was applied to the shaven skin of a male Lewis rat, a metabolic hydrolysis product, 2,3-dibromopropanol, was detected in free and conjugated form in the urine for several days.

来源:Hazardous Substances Data Bank (HSDB)

代谢

氧化代谢阻燃剂三-(2,3-二溴丙基)磷酸盐的大鼠肝微粒体产生了一种致突变代谢物。一种可能是O-脱烷基化到2,3-二溴丙醛，这是一种已知的烷基化剂。

Oxidative metab of the flame retardant tris-(2,3-dibromopropyl) phosphate by rat liver microsomes yields a mutagenic metabolite. One possibility is o-dealkylation to 2,3-dibromopropionaldehyde, a known alkylating agent.

来源:Hazardous Substances Data Bank (HSDB)

代谢

六种代谢物，是三溴化双酚A通过脱烷基和脱氢溴化反应产生的，在大鼠体内通过静脉注射和口服给药后，在尿液和胆汁中被识别，并且在体外通过大鼠肝脏中的还原型烟酰胺腺嘌呤二核苷酸依赖性微体酶形成。主要代谢物是双(2,3-二溴丙基)磷酸酯，其他包括三(2,3-二溴丙基)磷酸酯；2,3-二溴丙醇；2-溴-2-丙烯基；2,3-二溴丙基磷酸酯；双(2-溴-2-丙烯基)磷酸酯；2,3-二溴丙基磷酸酯；以及2-溴-2-丙烯基磷酸酯。

Six metabolites, products of dealkylation & dehydrobromination of tris-bp admin iv & orally to rats, were identified in urine & bile, & also formed in vitro by reduced nicotinamide adenine dinucleotide-dependent microsomal enzymes from rat liver. Major metabolite was bis(2,3-dibromopropyl)phosphate, others were tris(2,3-dibromopropyl)phosphate; 2,3-dibromopropanol; 2-bromo-2-propenyl; 2,3-dibromopropyl phosphate; bis(2-bromo-2-propenyl)phosphate; 2,3-dibromopropyl phosphate; & 2-bromo-2-propenyl phosphate.

来源:Hazardous Substances Data Bank (HSDB)

代谢

强突变剂2-溴丙烯醛是通过将致癌性阻燃剂三(2,3-二溴丙基)磷酸盐(tris-bp)与肝脏微粒体一起孵化形成的。用氘替换tris-bp末端碳原子(C-3)上的氢，显著降低了突变响应和2-溴丙烯醛的形成速率。通过质谱分析从选择性地氘化的tris-bp类似物形成的2-溴丙烯醛，揭示了2-溴丙烯醛形成的主要机制是在C-3位置首先发生氧化脱卤反应，然后发生β-消除反应。

The potent mutagen 2-bromacrolein is formed from the carcinogenic flame retardant tris(2,3-dibromopropyl)phosphate (tris-bp) on incubation with hepatic microsomes. Substitution of deuterium for hydrogen at the terminal carbon atoms (C-3) of tris-bp significantly decreased both the mutagenic response and the formation rate of 2-bromoacrolein. Mass spectral analysis of the 2-bromoacrolein that was formed from the selectively deuterated analogs of tris-bp revealed that the primary mechanism for the formation of 2-bromoacrolein involves an initial oxidative dehalogenation at C-3 followed by a beta-elimination reaction.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 致癌性证据

评估：对于三(2,3-二溴丙基)磷酸盐的人类致癌性，人类证据不足。对于三(2,3-二溴丙基)磷酸盐的致癌性，实验动物证据充分。总体评估：三(2,3-二溴丙基)磷酸盐可能对人类致癌（2A组）。在进行总体评估时，工作组考虑到三(2,3-二溴丙基)磷酸盐在广泛的哺乳动物体内和体外测试系统中均表现出活性。

Evaluation: There is inadequate evidence in humans for the carcinogenicity of tris(2,3-dibromopropyl)phosphate. There is sufficient evidence in experimental animals for the carcinogenicity of tris(2,3-dibromopropyl)phosphate. Overall evaluation: Tris(2,3-dibromopropyl)phosphate is probably carcinogenic to humans (Group 2A). In making the overall evaluation, the Working Group took into consideration that tris(2,3-dibromopropyl)phosphate is consistently active in a wide range of mammalian in vivo and in vitro test systems.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 致癌性证据

三(2,3-二溴丙基)磷酸盐根据实验动物研究中充分的致癌性证据，合理预期为人类致癌物。

Tris(2,3-dibromopropyl) phosphate is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 致癌物分类

国际癌症研究机构致癌物：三（2,3-二溴丙基）磷酸盐

IARC Carcinogenic Agent:Tris(2,3-dibromopropyl) phosphate

来源:International Agency for Research on Cancer (IARC)

毒理性

• 致癌物分类

国际癌症研究机构（IARC）致癌物分类：2A组：可能对人类致癌

IARC Carcinogenic Classes:Group 2A: Probably carcinogenic to humans

来源:International Agency for Research on Cancer (IARC)

毒理性

• 致癌物分类

国际癌症研究机构专著：第20卷：(1979年)一些卤代烃 增补第7卷：致癌性的总体评估：更新国际癌症研究机构专著第1至42卷，1987年；440页；ISBN 92-832-1411-0（已绝版） 第71卷：(1999年)对一些有机化学品、肼和过氧化氢的再评估（第1部分，第2部分，第3部分）

IARC Monographs:Volume 20: (1979) Some Halogenated Hydrocarbons Volume Sup 7: Overall Evaluations of Carcinogenicity: An Updating of IARC Monographs Volumes 1 to 42, 1987; 440 pages; ISBN 92-832-1411-0 (out of print) Volume 71: (1999) Re-evaluation of Some Organic Chemicals, Hydrazine and Hydrogen Peroxide (Part 1, Part 2, Part 3)

来源:International Agency for Research on Cancer (IARC)

吸收、分配和排泄

大约180微克/天（9微克/千克体重）的磷酸三（2,3-二溴丙基）通过穿着用磷酸三（2,3-二溴丙基）处理过的涤纶睡衣的儿童的皮肤被吸收。

Approx 180 ug/day (9 ug/kg body wt) tris(2,3-dibromopropyl) phosphate is absorbed through the skin of children wearing polyester pajamas /treated with tris(2,3-dibromopropyl) phosphate/.

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

Tris-BP是一种阻燃剂，通过口服和静脉注射14C标记的Tris-BP研究了其在雄性大鼠体内的代谢和分布。Tris-BP能够被消化道快速吸收并在体内广泛分布。无论是口服还是静脉注射，Tris-BP来源的放射性物质的分布和排泄情况相似。给药方式对组织分布的影响主要体现在口服给药后肝脏中浓度略高，而静脉注射后肺中浓度略高。24小时内，Tris-BP来源的放射性物质通过尿液、粪便和二氧化碳排出的比例约占剂量的50%。给药一天后，分析组织中的Tris-BP来源的放射性物质表明，所有组织中大部分放射性物质以各种代谢物的形式存在，而非母体化合物。大多数研究中组织的Tris-BP来源的放射性物质的最终清除最好用单一组分指数衰减来描述，半衰期约为2.5天。肝脏和肾脏的清除速度较慢，半衰期约为3.8天。大约33%的尿液中排出的放射性物质和大约50%的胆汁中排出的放射性物质通过高效液相色谱（HPLC）与合成标准共色谱法鉴定。通过这种方法，在尿液和胆汁中鉴定出六种代谢物和微量的母体化合物。这六种代谢物是母体化合物脱烷基和脱氢溴反应的产物。从尿液和胆汁中分离出的Tris-BP的代谢物也可以通过大鼠肝脏的NADPH依赖性微粒体酶在体外形成。肝脏的可溶性酶将Tris-BP代谢至少三种未识别的极性代谢物。

The metabolism and disposition of the flame retardant, tris(2,3-dibromopropyl)phosphate (Tris-BP), were studied after po and iv administration of the (14)C-labeled compound to the male rat. Tris-BP was readily absorbed from the gastrointestinal tract and rapidly distributed throughout the body. The distribution and excretion of Tris-BP derived radioactivity were similar after either po or iv administration. The only effects of route of administration on tissue distribution were slightly higher concentrations in liver after po administration and in lung after iv administration. The initial elimination of Tris-BP derived radioactivity in urine, feces, and as CO2 accounted for approximately 50% of the dose in 24 hr. An analysis of Tris-BP derived radioactivity remaining in the tissues one day after administration indicated that most of the radioactivity in all tissues was in the form of various metabolites rather than the parent compound. The terminal clearance of Tris-BP derived radioactivity from most of the tissues studied was best described by a single component exponential decay with a half-life of approximately 2.5 days. Clearance from liver and kidney was somewhat slower having a half-life of approximately 3.8 days. Approximately 33% of the radioactivity excreted in urine and approximately 50% of the radioactivity excreted in bile were identified by cochromatography with synthesized standards on high performance liquid chromatography (HPLC). Six metabolites and a trace of the parent compound were identified in urine and bile by this method. The six metabolites products of dealkylation and dehydrobromination of the parent compound. The metabolites of Tris-BP isolated from urine and bile were also formed in vitro by NADPH-dependent microsomal enzymes from rat liver. The soluble enzymes from liver metabolized Tris-BP to at least three unidentified polar metabolites.

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

三(2,3-二溴丙基)磷酸盐被从喂食100和1000毫克/千克饮食的雄性断奶大鼠的消化系统中吸收，持续28天。在28天的喂养后，在大鼠的肌肉、肝脏和脂肪中检测到与剂量相关的溴浓度；在停止给药6周后，这些浓度降至对照水平。当兔子每天通过皮肤应用500、1000和2000毫克/千克饮食的三(2,3-二溴丙基)磷酸盐时，其吸收呈剂量依赖性，通过血液中溴化物水平的增加可以证明。

Tris(2,3-dibromopropyl) phosphate was absorbed from the digestive system of male weanling rats fed 100 and 1000 mg/kg of diet for 28 days. Dose related bromine concn were detected ... in muscle, liver, and fat after 28 days' feeding; these concn were reduced to control levels 6 wk after admin of cmpd was discontinued. The absorption of tris(2,3-dibromopropyl) phosphate was dose dependent in rabbits that received daily skin applications of 500, 1000, and 2000 mg/kg of diet, as shown by incr blood bromide levels.

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

1972年至1976年间，大量婴儿和儿童可能通过皮肤吸收和偶尔通过口腔接触处理过的衣物摄入，接触了三(2,3-二溴-1-丙基)磷酸酯(TRIS)。

From 1972 to 1976, a significant number of infants and children were possibly exposed to tris(2,3-dibromo-1-propyl) phosphate (TRIS) mainly through skin absorption and occasionally through ingestion from oral contact with TRIS treated garments.

来源:Hazardous Substances Data Bank (HSDB)

安全信息

• 危险品标志：
  N,T
• 安全说明：
  S26,S37,S53,S61
• 危险类别码：
  R45
• WGK Germany：
  3
• 海关编码：
  2919100000
• 危险品运输编号：
  UN 3082 9/PG 3
• RTECS号：
  UB0350000

制备方法与用途

制备方法

工业上主要有以下两种制备方法。

合成制备方法

工业上主要有以下两种制备方法。

用途简介

1. 本品为广泛使用的含溴量很高的添加型阻燃剂，同时具有一定的增塑作用。可用于聚氯乙烯、聚苯乙烯、聚醋酸乙烯酯、软质和硬质聚氨酯泡沫塑料、不饱和聚酯、酚醛树脂、丙烯酸树脂、醋酸纤维素等多种塑料的阻燃。本品还可用于合成纤维和化学纤维。
2. 用作添加型阻燃剂，具有显著的阻燃效能和增塑作用。适用于酚醛树脂、丙烯酸树脂、不饱和聚酯、聚苯乙烯、聚氯乙烯、聚氨酯、醋酸纤维素、硝酸纤维素等。参考用量2～10份。

用途

1. 本品为广泛使用的含溴量很高的添加型阻燃剂，同时具有一定的增塑作用。可用于聚氯乙烯、聚苯乙烯、聚醋酸乙烯酯、软质和硬质聚氨酯泡沫塑料、不饱和聚酯、酚醛树脂、丙烯酸树脂、醋酸纤维素等多种塑料的阻燃。本品还可用于合成纤维和化学纤维。
2. 用作添加型阻燃剂，具有显著的阻燃效能和增塑作用。适用于酚醛树脂、丙烯酸树脂、不饱和聚酯、聚苯乙烯、聚氯乙烯、聚氨酯、醋酸纤维素、硝酸纤维素等。参考用量2～10份。

反应信息

• 作为反应物：
  描述：

  8-(1-ethyl-propyl)-6-methyl-2-trifluoromethyl-imidazo[1,2-b]pyridazine 、 5-(5-bromo-4-chloro-thiophen-2-yl)-1-methyl-1H-[1,2,4]triazole 、 potassium acetate 、 2,3-二溴-1-丙醇磷酸酯 在 四丁基溴化铵 、 醋酸钯 氮 作用下， 以 N-甲基吡咯烷酮 为溶剂， 反应 3.33h， 以to give the title compound (125 mg, 0.267 mmol, 40%)的产率得到3-[3-Chloro-5-(2-methyl-2H-[1,2,4]triazol-3-yl)-thiophen-2-yl]-8-(1-ethyl-propyl)-6-methyl-2-trifluoromethyl-imidazo[1,2-b]pyridazine
  参考文献：
  名称：

  Imidazopyridazine compounds

  摘要：

  本发明涉及新型的取代咪唑[1,2-b]吡啶嗪化合物（I），其制药组合物以及将此类化合物用作促肾上腺皮质激素释放因子1（CRF1）受体拮抗剂治疗精神障碍和神经疾病。

  公开号：

  US07612067B2
• 作为产物：
  描述：

  钾 、 双(2,3-丙基)酸盐 以tris-(2,3-dibromopropyl) phosphate was formed的产率得到2,3-二溴-1-丙醇磷酸酯
  参考文献：
  名称：

  Emulsifiers for durable flame retardant textile finishes

  摘要：

  使用卤代烷基磷酸及其盐作为三卤代脂肪酸酯在水系中的乳化剂，可用于制备耐久阻燃纺织品涂层。

  公开号：

  US04076630A1
• 作为试剂：
  描述：

  4-(1-ethyl-propyl)-2-methoxy-6-methyl-pyrrolo[1,2-b]pyridazine 、 5-(5-bromo-4-chloro-thiophen-2-yl)-1-methyl-1H-[1,2,4]triazole 、 potassium acetate 、 氮 、 乙酸乙酯 在 四丁基溴化铵 、 醋酸钯 、 2,3-二溴-1-丙醇磷酸酯 silica gel 、 乙酸乙酯 、 水 、 Sodium sulfate-III 、 crude material 作用下， 以 N-甲基吡咯烷酮 为溶剂， 反应 6.08h， 以gives the title compound (0.1062 g, 0.2469 mmol, 77%)的产率得到3-[3-chloro-5-(2-methyl-2H-[1,2,4]triazol-3-yl)-thiophen-2-yl]-8-(1-ethyl-propyl)-2,6-dimethyl-imidazo[1,2-b]pyridazine
  参考文献：
  名称：

  Imidazopyridazine Compounds

  摘要：

  本发明涉及一种新的取代咪唑[1,2-b]吡嗪化合物(I)，其药物组成物以及将这些化合物作为促肾上腺皮质激素释放因子1(CRF1)受体拮抗剂用于治疗精神障碍和神经系统疾病的用途。

  公开号：

  US20080113978A1

文献信息

• SULFENAMIDES AS FLAME RETARDANTS
  申请人：SONGWON INTERNATIONAL AG

  公开号：US20160289566A1

  公开（公告）日：2016-10-06

  The present invention is in the field of flame retardants and relates to use of sulfenamides as flame retardants, in particular in polymeric substrates.

  本发明属于阻燃剂领域，涉及将硫代酰胺用作阻燃剂，特别是在聚合物基材中的使用。
• BITTER TASTE MODIFIERS INCLUDING SUBSTITUTED 1-BENZYL-3-(1-(ISOXAZOL-4-YLMETHYL)-1H-PYRAZOL-4-YL)IMIDAZOLIDINE-2,4-DIONES AND COMPOSITIONS THEREOF
  申请人：SENOMYX, INC.

  公开号：US20160376263A1

  公开（公告）日：2016-12-29

  The present invention includes compounds and compositions known to modify the perception of bitter taste, and combinations of said compositions and compounds with additional compositions, compounds, and products. Exemplary compositions comprise one or more of the following: cooling agents; inactive drug ingredients; active pharmaceutical ingredients; food additives or foodstuffs; flavorants, or flavor enhancers; food or beverage products; bitter compounds; sweeteners; bitterants; sour flavorants; salty flavorants; umami flavorants; plant or animal products; compounds known to be used in pet care products; compounds known to be used in personal care products; compounds known to be used in home products; pharmaceutical preparations; topical preparations; cannabis-derived or cannabis-related products; compounds known to be used in oral care products; beverages; scents, perfumes, or odorants; compounds known to be used in consumer products; silicone compounds; abrasives; surfactants; warming agents; smoking articles; fats, oils, or emulsions; and/or probiotic bacteria or supplements.

  本发明涵盖已知用于改变苦味感知的化合物和组合物，以及所述组合物和化合物与额外的组合物、化合物和产品的组合。示例组合物包括以下一种或多种：冷却剂；无活性药物成分；活性药用成分；食品添加剂或食品；调味剂或调味增强剂；食品或饮料产品；苦味化合物；甜味剂；苦味剂；酸味调味剂；咸味调味剂；鲜味调味剂；植物或动物产品；已知用于宠物护理产品中的化合物；已知用于个人护理产品中的化合物；已知用于家用产品中的化合物；制药制剂；局部制剂；大麻衍生或与大麻相关的产品；已知用于口腔护理产品中的化合物；饮料；香味、香水或除臭剂；已知用于消费品中的化合物；硅化合物；磨料；表面活性剂；发热剂；吸烟物品；脂肪、油脂或乳化剂；和/或益生菌或补充剂。
• Nitrilases, nucleic acids encoding them and methods for making and using them
  申请人：Diversa Corporation

  公开号：US20040014195A1

  公开（公告）日：2004-01-22

  The invention relates to nitrilases and to nucleic acids encoding the nitrilases. In addition methods of designing new nitrilases and method of use thereof are also provided. The nitrilases have increased activity and stability at increased pH and temperature.

  该发明涉及腈酶和编码腈酶的核酸。此外还提供了设计新腈酶的方法以及使用该方法的方法。这些腈酶在较高的pH值和温度下具有增加的活性和稳定性。
• [EN] PHOSPHO-SUBSTITUTED ALKOXYAMINE COMPOUNDS<br/>[FR] COMPOSÉS ALCOXYAMINE SUBSTITUÉS PAR DES GROUPES PHOSPHO
  申请人：BASF SE

  公开号：WO2011086114A1

  公开（公告）日：2011-07-21

  The invention relates to compounds of the group of so-called sterically hindered amines (HALS) which are substituted by phospho groups. The invention also relates to flame retardant compositions wherein these compounds are added to the polymer substrate.

  该发明涉及一类所谓的受空间位阻影响的胺化合物（HALS），这些化合物被磷基取代。该发明还涉及阻燃组合物，其中这些化合物被添加到聚合物基质中。
• [EN] PHOSPHORUS-CONTAINING COMPOUNDS USEFUL FOR MAKING HALOGEN-FREE, IGNITION-RESISTANT POLYMERS<br/>[FR] COMPOSÉS PHOSPHORÉS UTILES POUR LA FABRICATION DE POLYMÈRES RÉSISTANT À L'INFLAMMATION ET EXEMPTS D'HALOGÈNE
  申请人：DOW GLOBAL TECHNOLOGIES INC

  公开号：WO2005118604A1

  公开（公告）日：2005-12-15

  Phosphorus-containing compounds are disclosed which are obtainable by reacting: (A) at least one organophosphorus compound having a group selected from the group H-P= 0 ; the group P-H and the group P-OH; and (B) at least one compound having the following Formula (I): Formula (I) [R'(Y)m']m(X - O - R')n wherein R' is an organic group; Y is a functional group selected from hydroxy, carboxylic acid, carboxylate, acid 15 anhydride, and amine; -SH, -SO3H, -CONH2, -NHCOOR, phosphite and phosphinate groups X is a hydrocarbylene group; R' is hydrogen or a hydrocarbyl group having from 1 to 8 carbon atoms, R is alkyl or aryl group having from 1 to 12 carbon atoms; m', m and n are, independently, numbers equal to or greater than 1. These compounds are useful for making flame retardant epoxy and polyurethane resins and ignition resistant thermoplastic resins, each of which is useful for a variety of end uses requiring flame retardancy or ignition resistance. Flame retardant epoxy resins may be used to make electrical laminates. Flame retardant polyurethane is useful for making rigid polyurethane foam used in construction and flexible polyurethane foam used to make vehicle upholstery. Ignition resistant thermoplastic resins are useful for making television cabinets, computer monitors, printer housings, automotive parts, and housings and parts for appliances. This invention is particularly useful in end use applications in which a low bromine or low halogen content is required or desired.

  本发明揭示了一种含磷化合物，其可通过反应获得：(A)至少一种有机磷化合物，该有机磷化合物具有从H-P=0组中选择的基团；P-H基团和P-OH基团；和(B)至少一种具有以下化学式(I)的化合物：化学式(I) [R'(Y)m']m(X - O - R')n，其中R'是有机基团；Y是从羟基、羧酸、羧酸盐、酸酐和胺中选择的功能基团；-SH、-SO3H、-CONH2、-NHCOOR、磷酸酯和亚磷酸盐基团；X是一个烃基烷基；R'是氢或具有1至8个碳原子的烃基基团，R是具有1至12个碳原子的烷基或芳基基团；m'、m和n分别是大于或等于1的数字。这些化合物可用于制备阻燃环氧树脂和聚氨酯树脂以及防火热塑性树脂，每种树脂都可用于各种需要阻燃性或防火性的最终用途。阻燃环氧树脂可用于制造电气层压板。阻燃聚氨酯树脂可用于制造建筑中使用的刚性聚氨酯泡沫和用于制造汽车座椅的柔性聚氨酯泡沫。防火热塑性树脂可用于制造电视柜、计算机显示器、打印机外壳、汽车零部件以及电器外壳和零部件。本发明特别适用于需要或期望低溴或低卤素含量的最终用途应用中。

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