2,5-二丙-2-基-1,3-二恶烷 | 25925-01-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二恶烷
• 中文名称: 2,5-二丙-2-基-1,3-二恶烷
• 英文名称: cis-2,5-Diisopropyl-1,3-dioxane
• 英文别名: 2,5-di(propan-2-yl)-1,3-dioxane
• CAS: 25925-01-3；25925-00-2
• 化学式: C₁₀H₂₀O₂
• 分子量: 172.26
• InChiKey: YAISJNQHUBKIPN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• ANTICANCER COMPOUNDS
  申请人：ST. JUDE CHILDREN'S RESEARCH HOSPITAL

  公开号：US20160009728A1

  公开（公告）日：2016-01-14

  In one aspect, the invention relates to compounds having anticancer activity; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating disorders associated with uncontrolled cellular proliferation using the compounds and compositions. This abstract is intended to be used as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

  本发明涉及具有抗癌活性的化合物；制备这些化合物的合成方法；包含这些化合物的制药组合物；以及使用这些化合物和组合物治疗与细胞不受控制增殖相关的疾病的方法。本摘要旨在作为在特定领域搜索的扫描工具使用，不旨在限制本发明。
• Liquid crystal composition and liquid crystal display including the same
  申请人：Samsung Display Co. Ltd.

  公开号：US10457868B2

  公开（公告）日：2019-10-29

  A liquid crystal composition, including at least one of: a first compound represented by Chemical Formula 1 below, a second compound represented by Chemical Formula 2 below; and a third compound represented by Chemical Formula 2′ below: The definitions of A, Z, n, R, and R′ are provided herein. Also provided is a liquid crystal display, including: a first display panel including a thin film transistor; a second display panel facing the first display panel; and a liquid crystal layer including at least one of a first compound represented by Chemical Formula 1, a second compound represented by Chemical Formula 2, and a third compound represented by Chemical Formula 2′ and a reactive mesogen.

  一种液晶组合物，包括以下至少一种：由以下化学式 1 表示的第一种化合物，由以下化学式 2 表示的第二种化合物，以及由以下化学式 2′表示的第三种化合物： 此处提供了 A、Z、n、R 和 R′的定义。还提供了一种液晶显示器，包括：第一显示面板，包括薄膜晶体管；第二显示面板，面向第一显示面板；以及液晶层，包括化学式 1 所代表的第一种化合物、化学式 2 所代表的第二种化合物和化学式 2′ 所代表的第三种化合物中的至少一种，以及反应介质。
• Method for the one-pot production of organo-iodinated compounds
  申请人：GUERBET

  公开号：US10836711B2

  公开（公告）日：2020-11-17

  The present invention concerns a process for the preparation of organo-iodized compounds, as well as their preparation intermediates. More particularly, the present invention concerns a process for the preparation of organo-iodized compounds which can be used as preparation intermediates in the synthesis of iodized contrast agents.

  本发明涉及一种制备有机碘化合物及其制备中间体的工艺。更具体地说，本发明涉及一种有机碘化化合物的制备工艺，该化合物可用作合成碘化造影剂的制备中间体。
• Nitrogen-containing condensed ring compounds having dopamine D3 antagonistic effect
  申请人：Shionogi & Co., Ltd.

  公开号：US11345716B2

  公开（公告）日：2022-05-31

  Novel compounds having D3 receptor antagonistic activity are provided. A compound represented by formula (I): wherein ring A is a heterocycle, X1 is each independently CR4aR4b, X2 is each independently CR4cR4d, Y1 and Y2 are each independently a carbon atom or a nitrogen atom, L is —N(R6)—C(═O)— or the like, W is cyclyl or the like, R2 and R3 are each independently substituted or unsubstituted alkyl or the like, R1a, R1b, R4a to R4d, and R6 are each independently hydrogen atoms or the like, p is 1 or 2, q is an integer of 1 to 3, n is an integer of 1 to 4, s is an integer of 0 to 4, or a pharmaceutically acceptable salt thereof.

  提供了具有 D3 受体拮抗活性的新型化合物。 由式（I）代表的化合物： 其中 环 A 是杂环，X1 各自独立地为 CR4aR4b，X2 各自独立地为 CR4cR4d，Y1 和 Y2 各自独立地为碳原子或氮原子、 L是-N(R6)-C(═O)-或类似物，W是环烷基或类似物，R2和R3各自独立地是取代或未取代的烷基或类似物，R1a、R1b、R4a至R4d和R6各自独立地是氢原子或类似物、 p 是 1 或 2，q 是 1 至 3 的整数，n 是 1 至 4 的整数，s 是 0 至 4 的整数，或其药学上可接受的盐。
• LIQUID CRYSTAL DISPLAY DEVICE AND LIQUID CRYSTAL COMPOSITION USED THEREFOR
  申请人：Samsung Display Co., Ltd.

  公开号：US20160304783A1

  公开（公告）日：2016-10-20

  A liquid crystal display device comprises a first substrate, a second substrate which faces the first substrate, an electrode part which is provided on at least one of the first substrate and the second substrate, and a liquid crystal layer which comprises a liquid crystal composition and is provided between the first substrate and the second substrate. The liquid crystal composition includes a liquid crystal compound of Formula 1. wherein R 1 , R 2 , A 11 , A 12 , A 13 , A 21 , A 22 , Z 11 , Z 12 , Z 13 , Z 21 , Z 22 , a, b, c, d, and e are as described herein.