2-(1-氨基-6-磺基萘-2-基氧基)乙酸 | 6373-39-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 中文名称: 2-(1-氨基-6-磺基萘-2-基氧基)乙酸
• 英文名称: [(1-Amino-6-sulfonaphthalen-2-yl)oxy]acetic acid
• 英文别名: 2-(1-amino-6-sulfonaphthalen-2-yl)oxyacetic acid
• CAS: 6373-39-3
• 化学式: C₁₂H₁₁NO₆S
• 分子量: 297.29
• InChiKey: XCOGAYHBZJLDOC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  135
• 氢给体数：
  3
• 氢受体数：
  7

安全信息

• 海关编码：
  2922509090

文献信息

• o-Aminoazoverbindungen
  申请人：BAYER AG

  公开号：EP0474039B1

  公开（公告）日：1994-11-09
• TETRAKISAZO DYES, THEIR PRODUCTION AND USE
  申请人：Clariant Finance (BVI) Limited

  公开号：EP0931109B1

  公开（公告）日：2003-02-26
• Small-molecule inhibitors of angiogenin and rnases and in vivo and in vitro methods of using same
  申请人：Shapiro Robert

  公开号：US20070032418A1

  公开（公告）日：2007-02-08

  Lead compounds were obtained in a high throughput screen (HTS) of angiogenin (ANG; a potent inducer of angiogenesis) enzyme activity, an RNase. One lead was shown to delay appearance of tumors in an animal tumor system, and to reduce the number of animals having tumors. Several lead compound analogs were found to be even more potent inhibitors of ANG activity compared to the original leads, and two were also found to have greater affinity for ANG than for pancreatic RNase. Other embodiments disclose a method comprising obtaining a ribonuclease inhibitor and a composition; and admixing the ribonuclease inhibitor and the composition to form an admixture, wherein a ribonuclease that may be present in the admixture is inhibited.
• Assays for identification of topoisomerase inhibitors
  申请人：Stivers T. James

  公开号：US20080020973A1

  公开（公告）日：2008-01-24

  The instant invention provides a continuous spectroscopic assay for DNA topoisomerase activity. The invention further provides topoisomerase inhibitors and pharmaceutical compositions for the treatment of topoisomerase associated diseases and disorders.
• US5183881A
  申请人：——

  公开号：US5183881A

  公开（公告）日：1993-02-02