2-(2,4-Dichlorophenoxy)-N'-((E)-{2-[(4-fluorobenzyl)oxy]-1-naphthyl}methylidene)butanohydrazide

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 2-(2,4-Dichlorophenoxy)-N'-((E)-{2-[(4-fluorobenzyl)oxy]-1-naphthyl}methylidene)butanohydrazide
• 英文别名: 2-(2,4-dichlorophenoxy)-N-[(E)-[2-[(4-fluorophenyl)methoxy]naphthalen-1-yl]methylideneamino]butanamide
• 化学式: C₂₈H₂₃Cl₂FN₂O₃
• 分子量: 525.4
• InChiKey: PSEOJYDDOOKBEK-KPGMTVGESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.9
• 重原子数：
  36
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  59.9
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• COMPOSITIONS FOR TREATMENT OF ALZHEIMER'S DISEASE
  申请人：Mount Sinai School Of Medicine Of New York University

  公开号：EP2413696A1

  公开（公告）日：2012-02-08
• [EN] COMPOSITIONS FOR TREATMENT OF ALZHEIMER'S DISEASE<br/>[FR] COMPOSITIONS POUR LE TRAITEMENT DE LA MALADIE D'ALZHEIMER
  申请人：SINAI SCHOOL MEDICINE

  公开号：WO2010114636A1

  公开（公告）日：2010-10-07

  The present invention includes Aβ-reducing and/or Aβ-anti-aggregation compounds and their uses in pharmaceutical compositions. The present invention further includes methods of formulating pharmaceutical compositions and methods of administering the compositions for treatment of Alzheimer's disease.