4-Furan-3-yl-7-[6-(3-hydroxy-6,8-dioxa-bicyclo[3.2.1]oct-3-yl)-pyridin-2-ylmethoxy]-naphthalene-2-carbonitrile

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 4-Furan-3-yl-7-[6-(3-hydroxy-6,8-dioxa-bicyclo[3.2.1]oct-3-yl)-pyridin-2-ylmethoxy]-naphthalene-2-carbonitrile
• 英文别名: 4-(furan-3-yl)-7-[[6-(3-hydroxy-6,8-dioxabicyclo[3.2.1]octan-3-yl)pyridin-2-yl]methoxy]naphthalene-2-carbonitrile
• 化学式: C₂₇H₂₂N₂O₅
• 分子量: 454.5
• InChiKey: LBKHEHIDDIEBSX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  34
• 可旋转键数：
  5
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  97.7
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• ETHER DERIVATIVES USEFUL AS INHIBITORS OF PDE4 ISOZYMES
  申请人：Marfat Anthony

  公开号：US20070161681A1

  公开（公告）日：2007-07-12

  Compounds useful as inhibitors of PDE4 in the treatment of diseases regulated by the activation and degranulation of eosinophils, especially asthma, chronic bronchitis, and chronic obstructive pulmonary disease, of the formula: wherein the substituents are as defined in the specification.

  以下化合物可用作PDE4的抑制剂，用于治疗由嗜酸性粒细胞的活化和脱颗粒调控的疾病，特别是哮喘、慢性支气管炎和慢性阻塞性肺疾病，其化学式如下：其中取代基如规范中所定义。
• METHODS AND COMPOSITIONS RELATING TO HEMATOLOGIC MALIGNANCIES
  申请人：Li Shaoguang

  公开号：US20120114605A1

  公开（公告）日：2012-05-10

  Methods of treating a subject having, or at risk of having, a myeloproliferative disorder are provided according to embodiments of the present invention which include administering a therapeutically effective amount of an arachidonate 5-lipoxygenase (5-LO) inhibitor to the subject. Combinations of therapeutic agents are administered according to embodiments of the present invention. In some embodiments, two or more 5-LO inhibitors are administered to a subject to treat a myeloproliferative disorder. In further embodiments, at least one 5-LO inhibitor and at least one additional therapeutic agent are administered to a subject to treat a myeloproliferative disorder. Methods of inhibiting leukemia stem cells are provided according to embodiments of the present invention which include contacting leukemia stem cells with an effective amount of an arachidonate 5-lipoxygenase inhibitor.
• US7183293B2
  申请人：——

  公开号：US7183293B2

  公开（公告）日：2007-02-27
• US7250518B2
  申请人：——

  公开号：US7250518B2

  公开（公告）日：2007-07-31
• US7312328B2
  申请人：——

  公开号：US7312328B2

  公开（公告）日：2007-12-25