3-[3-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-phenyl]-acrylic acid | 1010385-82-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 3-[3-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-phenyl]-acrylic acid
• 英文别名: (E)-3-[3-(5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)phenyl]prop-2-enoic acid
• CAS: 1010385-82-6
• 化学式: C₂₃H₂₆O₂
• 分子量: 334.458
• InChiKey: VOHFBDDTSLKLSC-DHZHZOJOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.6
• 重原子数：
  25
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Bicyclic aromatic compounds
  申请人：——

  公开号：US20030060491A1

  公开（公告）日：2003-03-27

  The invention relates to novel bicyclic aromatic compounds which have the general formula (I): 1 as well as to the use of these compounds in pharmaceutical compositions intended for use in human or veterinary medicine (dermatological, rheumatic, respiratory, cardiovascular and ophthalmological complaints in particular), or alternatively in cosmetic compositions.

  本发明涉及新型双环芳香化合物，其具有通式(I):1，以及在制备用于人类或兽医药物组合物（特别是皮肤科、风湿科、呼吸科、心血管科和眼科疾病），或者在化妆品组合物中使用这些化合物的用途。
• Assay for identification of compounds that promote melanin production and retinoid-like compounds identified by said assay
  申请人：Galderma Research & Development, S.N.C.

  公开号：US20030113281A1

  公开（公告）日：2003-06-19

  An in vitro assay for selecting compounds that alter pigmentation of skin is provided. Also, a novel class of pro-pigmentatory compounds is provided which comprise substituted aromatic or heterocyclic carboxylic acids, or derivatives thereof, or pharmaceutically acceptable salts, which do not contain a pheno, naphthol, thiophenol, or a thionaphthol function in free or protected form. In a preferred embodiment, thess compounds will display activity for RXRs. These compounds may be used for altering pigmentation of human skin and/or hair in cosmetic or dermatological compositions, and for the treatment of disorders and disease conditions that affect skin or hair pigmentation.

  提供了一种体外测定法，用于选择改变皮肤色素的化合物。此外，还提供了一类新型的促色素化合物，包括取代芳香或杂环羧酸或其衍生物或药学上可接受的盐，不含自由或保护形式的苯酚，萘酚，硫酚或硫代萘酚功能。在一种优选实施例中，这些化合物将显示出对RXRs的活性。这些化合物可用于改变人类皮肤和/或头发的色素，用于化妆品或皮肤科组合物，并用于治疗影响皮肤或头发色素的疾病和疾病状态。
• COMPOS S BICYCLIQUES-AROMATIQUES
  申请人：CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA, ( CIRD GALDERMA)

  公开号：EP0832081A1

  公开（公告）日：1998-04-01
• ASSAY FOR IDENTIFICATION OF COMPOUNDS THAT PROMOTE MELANIN PRODUCTION AND RETINOID-LIKE COMPOUNDS IDENTIFIED BY SAID ASSAY
  申请人：Galderma Research & Development, S.N.C.

  公开号：EP1082111A1

  公开（公告）日：2001-03-14
• EP1082111A4
  申请人：——

  公开号：EP1082111A4

  公开（公告）日：2004-03-10