6-(4-methoxy-benzyl)-7-(((naphthalene-1-carbonyl)amino)methyl)-2-(oxalyl-amino)-4,5,6,7-tetrahydro-thieno[2,3-c]pyridine-3-carboxylic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 6-(4-methoxy-benzyl)-7-(((naphthalene-1-carbonyl)amino)methyl)-2-(oxalyl-amino)-4,5,6,7-tetrahydro-thieno[2,3-c]pyridine-3-carboxylic acid
• 英文别名: 6-[(4-methoxyphenyl)methyl]-7-[(naphthalene-1-carbonylamino)methyl]-2-(oxaloamino)-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxylic acid
• 化学式: C₃₀H₂₇N₃O₇S
• 分子量: 573.626
• InChiKey: FEXFDFRLTLNDQC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  41
• 可旋转键数：
  9
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  174
• 氢给体数：
  4
• 氢受体数：
  9

文献信息

• MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPases)
  申请人：NOVO NORDISK A/S

  公开号：EP1214324B1

  公开（公告）日：2006-06-14
• US6410556B1
  申请人：——

  公开号：US6410556B1

  公开（公告）日：2002-06-25
• US7115624B1
  申请人：——

  公开号：US7115624B1

  公开（公告）日：2006-10-03
• [EN] MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPases)<br/>[FR] MODULATEURS DE PROTEINE TYROSINE PHOSPHATASE (PTPases)
  申请人：NOVO NORDISK AS

  公开号：WO2001019830A1

  公开（公告）日：2001-03-22

  The present invention provides novel compounds, novel compositions, methods of their use, and methods of their manufacture, where such compounds of Formula (1) are pharmacologically useful inhibitors of Protein Tyrosine Phosphatases (PTPase's) including PTP1B, T cell PTP, wherein n, m, X, R1, R2, R3, R4, R5, R6, and R7 are defined more fully in the description. The compounds are useful in the treatment of type I diabetes, type II diabetes, impaired glucose tolerance, insulin resistance, obesity, and other diseases.