1-benzyl-4-(3,4-dihydro-2H-chromen-4-yl)-1,4-diazepane

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 1-benzyl-4-(3,4-dihydro-2H-chromen-4-yl)-1,4-diazepane
• 化学式: C₂₁H₂₆N₂O
• 分子量: 322.4
• InChiKey: NJSPPZPDVLJAGR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  15.7
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• 1,4-DIAZACYCLOHEPTANE COMPOUNDS, PROCESS FOR THEIR PREPARATION, AND THEIR USE AS MEDICAMENTS
  申请人：AstraZeneca AB

  公开号：EP1140891A1

  公开（公告）日：2001-10-10
• [EN] 1,4-DIAZACYCLOHEPTANE COMPOUNDS, PROCESS FOR THEIR PREPARATION, AND THEIR USE AS MEDICAMENTS<br/>[FR] COMPOSES DE 1,4-DIAZACYCLO-HEPTANE, PROCEDEEDE PREPARATION ET APPLICATIONS MEDICAMENTEUSES
  申请人：ASTRAZENECA UK LTD

  公开号：WO2000040574A1

  公开（公告）日：2000-07-13

  1,4-Diazacyclo-heptanes of formula (I) wherein R is selected from hydrogen, C1-10alkyl, C2-8alkenyl, C3-8cycloalkyl, C3-8cycloalkyl C1-6alkyl, phenylC1-6alkyl and phenyl, R1 at each occurrence is independently selected from hydrogen, C¿1-6?alkyl, C2-6alkenyl, C1-6alkoxy, halo, hydroxy, C1-6alkanoyl, haloC1-6alkyl, cyano and nitro, m is 4, R?2¿ at each occurrence is independently selected from hydrogen and C¿1-6?alkyl, and n is 4, together with processes for their manufacture and compositions containing them. Compounds of formula (I) are pharmacologically useful.