3,6-diamino-9-(2,5-dicarboxyphenyl)-4,5-disulfo-Xanthylium

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 3,6-diamino-9-(2,5-dicarboxyphenyl)-4,5-disulfo-Xanthylium
• 英文别名: 2-(3-amino-6-imino-4,5-disulfoxanthen-9-yl)terephthalic acid
• 化学式: C₂₁H₁₄N₂O₁₁S₂
• 分子量: 534.5
• InChiKey: KRKUDGHUGTVPJN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  36
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  259
• 氢给体数：
  6
• 氢受体数：
  13

文献信息

• LABELING REAGENTS AND METHODS OF THEIR USE
  申请人：Antoulinakis Evan

  公开号：US20090004753A1

  公开（公告）日：2009-01-01

  The present disclosure is directed to a reactive ester agent capable of conjugating a reporter molecule to a carrier molecule or solid support. The reactive ester agent has the general formula: wherein the variables are described throughout the application.

  本公开涉及一种反应性酯试剂，能够将报告分子与载体分子或固体支持物共轭。该反应性酯试剂具有以下通式：其中变量在本申请中进行了描述。
• Labeling Reagents and Methods of Their Use
  申请人：LIFE TECHNOLOGIES CORPORATION

  公开号：US20150355186A1

  公开（公告）日：2015-12-10

  The present disclosure is directed to a reactive ester agent capable of conjugating a reporter molecule to a carrier molecule or solid support. The reactive ester agent has the general formula: wherein the variables are described throughout the application.

  本公开涉及一种反应性酯试剂，能够将报告分子与载体分子或固体支持物结合。反应性酯试剂具有以下通式：其中变量在整个申请中描述。
• METHOD FOR DETECTING SINGLE BASE SUBSTITUTION USING ION EXCHANGE CHROMATOGRAPHY
  申请人：Sekisui Medical Co., Ltd.

  公开号：EP3690039A1

  公开（公告）日：2020-08-05

  An object of the present invention is to provide a method for accurately and quantitatively discriminating and detecting a wide variety of gene mutations, or particularly, single base substitutions or point mutations. In an ASP for analyzing gene mutations, or particularly, single base substitutions or point mutations, when a non-nucleotide component is added to the 5' end of at least one of the ASP and a primer paired therewith before amplification by PCR and amplification products thereof are separated by ion-exchange chromatography, even the amplification products having the same length can be separated and detected.

  本发明的目的是提供一种方法，用于准确和定量地鉴别和检测各种基因突变，特别是单碱基替换或点突变。在用于分析基因突变，特别是单碱基置换或点突变的 ASP 中，如果在 PCR 扩增前在至少一种 ASP 的 5'端和与之配对的引物中加入非核苷酸成分，并用离子交换色谱法分离其扩增产物，即使是具有相同长度的扩增产物也能被分离和检测出来。
• US8586743B2
  申请人：——

  公开号：US8586743B2

  公开（公告）日：2013-11-19
• US9140706B2
  申请人：——

  公开号：US9140706B2

  公开（公告）日：2015-09-22