2-[3-Chloro-2-[(2-methoxynaphthalen-1-yl)sulfanylmethyl]phenyl]-1,4,5,6-tetrahydropyrimidine

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 2-[3-Chloro-2-[(2-methoxynaphthalen-1-yl)sulfanylmethyl]phenyl]-1,4,5,6-tetrahydropyrimidine
• 化学式: C₂₂H₂₁ClN₂OS
• 分子量: 396.9
• InChiKey: WUPHVXHCTSWGPA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  27
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  58.9
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Melanocortin-4 receptor binding compounds and methods of use thereof
  申请人：Millennium Pharmaceuticals, Inc.

  公开号：US20040082779A1

  公开（公告）日：2004-04-29

  Provided are MC4-R binding compounds of the formula XVII: 1 wherein L 2 is a linker group, and P 1 , P 2 , P 3 , P 4 , Z 1 , Z 2 , Z 3 , Z 4 , Z 5 , t, s, and R are as described in the specification. Methods of using the compounds to treat MC4-R associated disorders, such as disorders associated with weight loss, are also provided.

  提供了具有以下化学式XVII的MC4-R结合化合物： 其中L2是连接基团，P1、P2、P3、P4、Z1、Z2、Z3、Z4、Z5、t、s和R如规范中所述。还提供了使用这些化合物治疗与MC4-R相关疾病的方法，例如与体重减轻相关的疾病。
• MELANOCORTIN-4 RECEPTOR BINDING COMPOUNDS AND METHODS OF USE THEREOF
  申请人：Millennium Pharmaceuticals, Inc.

  公开号：EP1204645A2

  公开（公告）日：2002-05-15
• US6699873B1
  申请人：——

  公开号：US6699873B1

  公开（公告）日：2004-03-02
• US7375125B2
  申请人：——

  公开号：US7375125B2

  公开（公告）日：2008-05-20
• [EN] MELANOCORTIN-4 RECEPTOR BINDING COMPOUNDS AND METHODS OF USE THEREOF<br/>[FR] COMPOSES FIXANT LES RECEPTEURS DE MELANOCORTINE-4 ET PROCEDES D'UTILISATION DE CES COMPOSES
  申请人：MILLENNIUM PHARM INC

  公开号：WO2001010842A2

  公开（公告）日：2001-02-15

  MC4-R binding compounds of the formula (I): B-Z-E wherein B is an anchor moiety, Z is a central moiety, and E is an MC4-R interacting moiety are discussed. Methods of using the compounds to treat MC4-R associated disorders, such as disorders associated with weight loss, are also discussed.