2-bromo-1-(4-methylpiperazin-1-yl)ethan-1-one | 112257-15-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 2-bromo-1-(4-methylpiperazin-1-yl)ethan-1-one
• 英文别名: 1-(bromoacetyl)-4-methylpiperazine；2-Bromo-1-(4-methylpiperazin-1-yl)ethanone
• CAS: 112257-15-5
• 化学式: C₇H₁₃BrN₂O
• mdl: MFCD15205977
• 分子量: 221.097
• InChiKey: DIAFTBFWJHPDIW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  23.6
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-bromo-1-(4-methylpiperazin-1-yl)ethan-1-one 、 对氨基苯酚 以to give a product of m.p. 71°-73° C.的产率得到1-<(4-aminophenoxy)acetyl>-4-methylpiperazine
  参考文献：
  名称：

  4,5,6-substituted-N-(substituted-phenyl)-2-pyrimidinamines

  摘要：

  本披露描述了具有抗哮喘活性的新型4,5,6-取代-N-(取代苯基)-2-嘧啶胺。

  公开号：

  US04788195A1
• 作为产物：
  描述：

  N-甲基哌嗪 、 溴乙酰氯 以 乙醚 为溶剂， 反应 4.0h， 生成 2-bromo-1-(4-methylpiperazin-1-yl)ethan-1-one
  参考文献：
  名称：

  Anthraquinone based near IR emitting compounds and uses thereof

  摘要：

  揭示了近红外发射荧光化合物；制备方法和包含所述化合物的试剂盒；以及它们在基于荧光的生物材料检测中的应用。

  公开号：

  US08999965B2

文献信息

• Benzoheterocyclic derivatives
  申请人：Otsuka Pharmaceuticals Co., Ltd.

  公开号：US06335327B1

  公开（公告）日：2002-01-01

  A benzoheterocyclic derivative of the following formula [1]: and pharmaceutically acceptable salts thereof, which show excellent anti-vasopressin activity, vasopressin agonistic activity and oxytocin antagonistic activity, and are useful as a vasopressin antagonist, vasopressin agonist or oxytocin antagonist.

  以下是该句子的中文翻译： 一种苯并杂环衍生物，其化学式如下： 及其药用盐，表现出优异的抗加压素活性、加压素激动活性和催产素拮抗活性，可用作加压素拮抗剂、加压素激动剂或催产素拮抗剂。
• [EN] THERAPEUTIC COMPOUNDS AND USES THEREOF<br/>[FR] COMPOSÉS THÉRAPEUTIQUES ET LEURS UTILISATIONS
  申请人：GENENTECH INC

  公开号：WO2016123387A1

  公开（公告）日：2016-08-04

  Provided herein are compounds of formula I: and salts thereof and compositions and uses thereof. The compounds are useful as inhibitors of LSD1. Also included are pharmaceutical compositions comprising a compound of formula I or a pharmaceutically acceptable salt thereof, and methods of using such compounds and salts in the treatment of various LSD1-mediated disorders.

  本文提供了公式I的化合物及其盐、组合物和用途。这些化合物可用作LSD1的抑制剂。还包括含有公式I化合物或其药用盐的药物组合物，以及在治疗各种LSD1介导的疾病中使用这些化合物和盐的方法。
• ANTHRAQUINONE BASED NEAR IR EMITTING COMPOUNDS AND USES THEREOF
  申请人：Yue Stephen

  公开号：US20120028249A1

  公开（公告）日：2012-02-02

  Disclosed are near IR emitting fluorescent compounds; methods of making and kits containing the described compounds; and their use in fluorescence-based detection of biological materials.

  揭示了近红外发射荧光化合物；制备方法和包含所述化合物的试剂盒；以及它们在基于荧光的生物材料检测中的应用。
• Nucleic-acid triggered release of molecules
  申请人：Riken

  公开号：EP2105146A1

  公开（公告）日：2009-09-30

  It is an object of the present invention to provide a method for highly selectively releasing a molecule of interest such as an agent at a desired site while suppressing the influence of catabolic enzymes existing in vivo. The present invention provides a method for releasing a molecule of interest, which comprises steps of: hybridizing each of an "electron donor-first nucleic acid probe" molecule formed by binding an electron donor structure to a first nucleic acid probe having a nucleotide sequence complementary to a portion of a target nucleic acid sequence and a "molecule of interest-electron acceptor-second nucleic acid probe" molecule formed by binding an electron acceptor structure having a molecule of interest and an azide group to a second nucleic acid probe that has a nucleotide sequence complementary to said target nucleic acid sequence and differing from that of said first nucleic acid probe, to said target nucleic acid sequence; and allowing said "electron donor-first nucleic acid probe" molecule to act on said "molecule of interest-electron acceptor-second nucleic acid probe" molecule, so as to release said molecule of interest.

  本发明的目的是提供一种高度选择性地在所需位置释放感兴趣的分子（如药物），同时抑制体内存在的分解酶的影响的方法。本发明提供了一种释放感兴趣分子的方法，包括以下步骤：将电子给体结构与具有与目标核酸序列部分互补的第一核酸探针结合形成的“电子给体-第一核酸探针”分子和将具有感兴趣分子和叠氮基团的电子受体结构与具有与目标核酸序列互补且与第一核酸探针不同的第二核酸探针结合形成的“感兴趣分子-电子受体-第二核酸探针”分子与目标核酸序列杂交；并使“电子给体-第一核酸探针”分子作用于“感兴趣分子-电子受体-第二核酸探针”分子，以释放所述感兴趣分子。
• Biaryl Heterocyclic Compounds And Methods Of Making And Using The Same
  申请人：Zhou Jiacheng

  公开号：US20120010200A1

  公开（公告）日：2012-01-12

  The present invention relates generally to the field of anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents. More particularly, the invention relates to a family of compounds having both a biaryl moiety and at least one heterocylic moiety that are useful as such agents.

  本发明通常涉及抗感染、抗增殖、抗炎和促动力剂领域。更具体地说，本发明涉及一类化合物家族，具有双芳基基团和至少一个杂环基团，可用作上述药剂。