bis(2-piperazinoethyl) disulfide | 148193-00-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: bis(2-piperazinoethyl) disulfide
• 英文别名: Bis-<2-(piperazinyl-(1))-ethyl>-disulfid；1,1'-(3,4-dithia-hexane-1,6-diyl)-bis-piperazine；1-[2-(2-Piperazin-1-ylethyldisulfanyl)ethyl]piperazine
• CAS: 148193-00-4
• 化学式: C₁₂H₂₆N₄S₂
• 分子量: 290.497
• InChiKey: HYMWTFWNXTYDRX-UHFFFAOYSA-N

物化性质

• 沸点：
  439.0±45.0 °C(Predicted)
• 密度：
  1.110±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  18
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  81.1
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  bis(2-piperazinoethyl) disulfide 、 季戊四醇缩水甘油醚 以 甲醇 为溶剂， 反应 18.08h， 生成 1-[4-[2-[2-[4-[2-Hydroxy-3-[3-(oxiran-2-ylmethoxy)-2,2-bis(oxiran-2-ylmethoxymethyl)propoxy]propyl]piperazin-1-yl]ethyldisulfanyl]ethyl]piperazin-1-yl]-3-[3-(oxiran-2-ylmethoxy)-2,2-bis(oxiran-2-ylmethoxymethyl)propoxy]propan-2-ol
  参考文献：
  名称：

  [EN] DENDRITIC POLYMERS WITH ENHANCED AMPLIFICATION AND INTERIOR FUNCTIONALITY
  [FR] POLYMERES DENDRITIQUES AVEC FONCTIONNALITE INTERIEURE ET AMPLIFICATION RENFORCEES

  摘要：

  公开号：

  WO2006115547A3
• 作为产物：
  描述：

  2-mercaptoethylpiperazine 生成 bis(2-piperazinoethyl) disulfide
  参考文献：
  名称：

  使用芳烃-钌化学制备供体-sigma-受体分子。

  摘要：

  已通过钌活化的亲核芳香族取代（S（N）Ar）反应制备了具有硫代烷基侧链的几个供体-σ受体（D-sigma-A）分子。解决了通过使用哌嗪衍生物作为亲核试剂从环戊二烯基（1,4-二氯苯）钌中选择性取代氯的方法。这种选择性与配合物的进一步处理相结合，可以制备不对称官能化的四烷基对苯二胺（TAPD）单元，这些单元很难通过传统的有机S（N）Ar条件合成。描述了在紫外辐射下苯并菲对芳烃-RuCp体系的分解。

  DOI：

  10.1021/jo000018s

文献信息

• Dendritic polymers with enhanced amplification and interior functionality
  申请人：Dendritic Nanotechnologies Inc.

  公开号：EP2325236A1

  公开（公告）日：2011-05-25

  Dendritic polymers of the macromolecular structure of Figur 1 are disclosed. The dendritic polymers have enhanced amplification and interior functionality. The dendritic polymers are made by use of fact, reactive ring-opening chemistry (or other fast reactions) combined with the use of branch cell reagents in a controlled manner to rapidly and precisely build dendritic structures with cleaner chemistry and often with single products. Additional benefits include lower excesses of regents, lower levels of dilution, higher capacity, more easily scaled to commercial dimensions, new ranges of materials, and lower cost. The compositions prepared have novel internal functionality, including increased thermal stability and no reverse Michael's reaction, and reach encapsulation surface densities at lower generations.

  图 1 公开了大分子结构的树枝状聚合物。树枝状聚合物具有更强的放大和内部功能。树枝状聚合物是通过使用事实、反应性开环化学（或其他快速反应），结合使用分支细胞试剂，以受控的方式快速、精确地构建树枝状结构，化学反应更纯净，通常只有单一产物。其他优点还包括：调节剂用量更少、稀释程度更低、容量更大、更容易扩展到商业规模、材料范围更广、成本更低。所制备的组合物具有新颖的内部功能性，包括热稳定性更高，不会发生迈克尔反向反应，并能在较低世代达到封装表面密度。
• DENDRITIC POLYMERS WITH ENHANCED AMPLIFICATION AND INTERIOR FUNCTIONALITY
  申请人：Dendritic Nanotechnologies, Inc.

  公开号：EP1877103A2

  公开（公告）日：2008-01-16
• Dendritic Polymers With Enhanced Amplification and Interior Functionality
  申请人：Tomalia A. Donald

  公开号：US20070298006A1

  公开（公告）日：2007-12-27

  Dendritic polymers with enhanced amplification and interior functionality are disclosed. These dendritic polymers are made by use of fast, reactive ring-opening chemistry (or other fast reactions) combined with the use of branch cell reagents in a controlled way to rapidly and precisely build dendritic structures, generation by generation, with cleaner chemistry, often single products, lower excesses of reagents, lower levels of dilution, higher capacity method, more easily scaled to commercial dimensions, new ranges of materials, and lower cost. The dendritic compositions prepared have novel internal functionality, greater stability (e.g., thermal stability and less or no reverse Michael's reaction), and reach encapsulation surface densities at lower generations. Unexpectedly, these reactions of polyfunctional branch cell reagents with polyfunctional cores do not create cross-linked materials. Such dendritic polymers are useful as demulsifiers for oil/water emulsions, wet strength agents in the manufacture of paper, proton scavengers, polymers, nanoscale monomers, calibration standards for electron microscopy, making size selective membranes, and agents for modifying viscosity in aqueous formulations such as paint. When these dendritic polymers have a carried material associated with their surface and/or interior, then these dendritic polymers have additional properties for carrying materials due to the unique characteristics of the dendritic polymer, such as for drug delivery, transfection, and diagnostics.
• US7985424B2
  申请人：——

  公开号：US7985424B2

  公开（公告）日：2011-07-26
• [EN] DENDRITIC POLYMERS WITH ENHANCED AMPLIFICATION AND INTERIOR FUNCTIONALITY<br/>[FR] POLYMERES DENDRITIQUES AVEC FONCTIONNALITE INTERIEURE ET AMPLIFICATION RENFORCEES
  申请人：DENDRITIC NANOTECHNOLOGIES INC

  公开号：WO2006115547A3

  公开（公告）日：2009-06-04